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Randomized Double-Blind Placebo-Controlled Study of the Safety Tolerability and Clinical Effect of Danirixin in Adults With Acute Uncomplicated Influenza

机译：Danirixin在成人急性复杂性流感中的安全性耐受性和临床疗效的随机双盲安慰剂对照研究

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BackgroundDanirixin (DNX), a selective and reversible CXC chemokine receptor 2 antagonist, inhibits neutrophil transmigration and activation. This study assessed the safety, tolerability, and clinical effect of DNX with and without oseltamivir (OSV) in adults with acute, uncomplicated influenza.

机译：背景Danirixin（DNX）是一种选择性且可逆的CXC趋化因子受体2拮抗剂，可抑制嗜中性粒细胞的迁移和激活。这项研究评估了在患有急性单纯性流感的成人中使用或不使用奥司他韦（OSV）的DNX的安全性，耐受性和临床效果。

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期刊名称 Open Forum Infectious Diseases
作者
Grace Roberts; Shuguang Chen; Phillip Yates; Anuradha Madan; Jill Walker; Michael L Washburn; Andrew J Peat; Gary Soucie; Edward Kerwin; Sumita Roy-Ghanta;
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作者单位

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年(卷),期 2019(6),4
年度 2019
页码 ofz072
总页数 8
原文格式 PDF
正文语种
中图分类病毒传染病;
关键词
CXC chemokine receptor 2 (CXCR2) antagonist danirixin (DNX) influenza outpatient safety;

机译：CXC趋化因子受体2（CXCR2）拮抗剂;丹尼新（DNX）;流行性感冒;门诊;安全性;

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专利

1. Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Tolerability, and Clinical Effect of Danirixin in Adults With Acute, Uncomplicated Influenza [J] . Grace Roberts, Shuguang Chen, Phillip Yates, Open Forum Infectious Diseases . 2019,第4期

机译：Danirixin在成人急性，复杂性流感中的安全性，耐受性和临床疗效的随机，双盲，安慰剂对照研究
2. Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo-controlled study [J] . Ellie Hershberger, Susan Sloan, Kristin Narayan, EBioMedicine . 2019,第164期

机译：单纯抗体VIS410在成人非复杂性A型流感感染中的安全性和有效性：一项随机，双盲，2期，安慰剂对照研究的结果
3. Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: A double-blind, randomised, placebo-controlled, phase 2b/3 trial [J] . HaffizullaJ., HartmanA., HoppersM., The Lancet infectious diseases . 2014,第7期

机译：硝唑尼特对成人和青少年急性并发流行性感冒的影响：一项双盲，随机，安慰剂对照的2b / 3期试验
4. EFFECT OF TARGETED PULSED ELECTROMAGNETIC FIELD THERAPY ON CANINE POST-OPERATIVE HEMILAMINECTOMY: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED CLINICAL TRIAL [C] . ACVS Veterinary Symposium . 2018

机译：靶向脉冲电磁场治疗对犬术后血栓切除术的影响：双盲，随机，安慰剂对照临床试验
5. A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil (Eicosapentaenoic Acid and Docosahexaenoic Acid) on Lung and Systemic Inflammation in Patients with Acute Lung Injury. [D] . Stapleton, Renee Doney. 2010

机译：鱼油（二十碳五烯酸和二十二碳六烯酸）对急性肺损伤患者的肺和全身炎症的II期，随机，双盲，安慰剂对照试验。
6. Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized double-blind phase-2 placebo-controlled study [O] . Ellie Hershberger, Susan Sloan, Kristin Narayan, 2019

机译：单纯抗体VIS410在成人非复杂性A型流感感染中的安全性和有效性：一项随机双盲2期安慰剂对照研究的结果
7. Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Tolerability, and Clinical Effect of Danirixin in Adults With Acute, Uncomplicated Influenza [O] . Grace Roberts, Shuguang Chen, Phillip Yates, 2019

机译：随机，双盲，安慰剂对照研究Danirixin与急性，简单的流感丹霞汀的安全性，耐受性和临床影响

Randomized Double-Blind Placebo-Controlled Study of the Safety Tolerability and Clinical Effect of Danirixin in Adults With Acute Uncomplicated Influenza

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