Interleukin-6 does not upregulate pro-inflammatory cytokine expression in an ex vivo model of giant cell arteritis

机译：白细胞介素6不会在巨细胞性动脉炎的离体模型中上调促炎性细胞因子的表达

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ObjectiveThe aim of this study was to examine the pro-inflammatory effects of IL-6 in ex vivo temporal artery explant cultures.

机译：目的本研究的目的是检查IL-6在离体颞动脉外植体培养物中的促炎作用。

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期刊名称 Rheumatology Advances in Practice
作者
Lorraine O’Neill; Jennifer McCormick; Wei Gao; Douglas J Veale; Geraldine M McCarthy; Conor C Murphy; Ursula Fearon; Eamonn S Molloy;
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作者单位

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年(卷),期 2019(3),1
年度 2019
页码 rkz011
总页数 9
原文格式 PDF
正文语种
中图分类免疫性疾病;
关键词
giant cell arteritis interleukin-6 temporal artery culture tocilizumab;

机译：巨细胞动脉炎;白介素6;颞动脉培养;托珠单抗;

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专利

1. Cytokine expression in temporal arteries: comparative analysis between patients with biopsy-positive giant cell arteritis, biopsy-negative giant cell arteritis and biopsy-negative without arteritis [J] . Grossman C., Yassin N., Avivi C., Clinical and experimental rheumatology . 2019,第2Suppla117期

机译：颞型动脉中的细胞因子表达：活组织检查阳性细胞炎患者的比较分析，活组织检查阴性巨细胞动脉炎，活检 - 阴性无动脉炎
2. Tissue production of pro-inflammatory cytokines (IL-1beta, TNFalpha and IL-6) correlates with the intensity of the systemic inflammatory response and with corticosteroid requirements in giant-cell arteritis. [J] . Hernandez Rodriguez J, Segarra M, Vilardell C, Rheumatology . 2004,第3期

机译：炎性细胞因子（IL-1beta，TNFalpha和IL-6）的组织产生与全身炎性反应的强度以及巨细胞性动脉炎中皮质类固醇的需求有关。
3. Clinical Relevance of Persistently Elevated Circulating Cytokines (Tumor Necrosis Factor a and Interleukin-6) in the Long-Term Followup of Patients With Giant Cell Arteritis [J] . ANA GARCIA-MARTINEZ, JOSE HERNANDEZ-RODRIGUEZ, GEORGINA ESPIGOL-FRIGOLE, Arthritis care & research . 2010,第6期

机译：持续性循环细胞因子（肿瘤坏死因子a和白细胞介素6）持续升高在巨细胞性动脉炎患者长期随访中的临床意义
4. THE EXPRESSION OF COX-2 AND PRO-INFLAMMATORY CYTOKINES INDUCED BY PCB IN HUMAN MAST CELLS REQUIRES NF-k kk kB ACTIVATION [C] . O-Kyun Kwon, Eunkyung Lee, Tae Chul Moon, International symposium on halogenated environmental organic pollutants and persistent organic pollutants and POPs;DIOXIN;DIOXIN 2001;POPs . 2001

机译：PCB诱导的乳腺癌细胞中COX-2的表达和促炎性细胞因子的激活需要NF-k kk kB的激活
5. In vivo kinetics of early cytokine expression in the Lactobacillus cell wall extract-based mouse model of Kawasaki disease. [D] . Kumar, Ashesh. 2002

机译：川崎病基于乳杆菌细胞壁提取物的小鼠模型中早期细胞因子表达的体内动力学。
6. Collagen-derived N-acetylated proline-glycine-proline upregulates the expression of pro-inflammatory cytokines and extracellular matrix proteases in nucleus pulposus cells via the NF-κB and MAPK signaling pathways [O] . Chencheng Feng, Jinyue He, Yang Zhang, -1

机译：胶原蛋白衍生的N-乙酰化脯氨酸-甘氨酸-脯氨酸通过NF-κB和MAPK信号通路上调髓核细胞中促炎性细胞因子和细胞外基质蛋白酶的表达
7. Interleukin-6 does not upregulate pro-inflammatory cytokine expression in an ex vivo model of giant cell arteritis [O] . Lorraine O’Neill, Jennifer McCormick, Wei Gao, 2019

机译：白细胞介素-6在巨型细胞动脉炎前体内模型中不上调促炎细胞因子表达

Interleukin-6 does not upregulate pro-inflammatory cytokine expression in an ex vivo model of giant cell arteritis

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