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Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a open-label study

机译：Verinurad联合非布索坦治疗日本成人痛风或无症状高尿酸血症：2a期开放标签研究

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ObjectivesVerinurad (RDEA3170) is a high-affinity inhibitor of the URAT1 transporter in clinical development for treating gout and asymptomatic hyperuricaemia. The aim of this Phase 2a, randomized, open-label study was to investigate the multiple-dose pharmacodynamics, pharmacokinetics and safety of oral verinurad combined with febuxostat vs febuxostat alone and verinurad alone.

机译：目的Verinurad（RDEA3170）是URAT1转运蛋白的高亲和力抑制剂，在临床开发中用于治疗痛风和无症状高尿酸血症。这项2a期随机，开放标签研究的目的是研究口服verinurad联合非布索坦vs单独与非布索坦和单独与verinurad联合使用的多剂量药效学，药代动力学和安全性。

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期刊名称 Rheumatology (Oxford England)
作者
Masanari Shiramoto; Sha Liu; Zancong Shen; Xiaohong Yan; Amy Yamamoto; Michael Gillen; Yasushi Ito; Jesse Hall;
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作者单位

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年(卷),期 -1(57),9
年度 -1
页码 1602–1610
总页数 9
原文格式 PDF
正文语种
中图分类免疫性疾病;
关键词
verinurad febuxostat pharmacokinetics pharmacodynamics serum urate hyperuricemia gout;

机译：verinurad;非布索坦;药代动力学;药效学;血清尿酸盐;高尿酸血症;痛风;
入库时间 2022-08-21 10:58:45

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专利

1. Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a, open-label study [J] . Shiramoto Masanari, Liu Sha, Shen Zancong, Rheumatology . 2018,第9期

机译：Verinurad与日本成年人的Febuxostat联合痛风或无症状的高尿素：一个第2A期，开放标签研究
2. Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with allopurinol in adults with gout: a phase IIa, open-label study [J] . Sha Liu, Jeffrey N Miner, Martha Hernandez-Illas, RMD Open . 2018,第1期

机译：Verinurad与别嘌呤醇联合治疗成人痛风的药效学，药代动力学作用和安全性：IIa期开放标签研究
3. An allopurinol-controlled, multicenter, randomized, open-label, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 2 exploratory clinical study. [J] . Naoyuki K, Shin F, Toshikazu H, Journal of clinical rheumatology . 2011,第S2期

机译：别嘌呤醇控制的多中心，随机，开放标签，组间平行的非布索坦（TMX-67）的对比研究，非嘌呤黄嘌呤氧化酶的选择性抑制剂，用于高尿酸血症患者，包括日本的痛风患者： 2期探索性临床研究。
4. Pharmacokinetics and Tolerability of Sublingual Fentanyl in Healthy Japanese and Caucasian Volunteers: Phase I, Open-Label Single-Dose Study [C] . U. Lorch, F. Farrell, J. Kilborn, International Pain Clinic Congress . 2008

机译：健康日本和白种人志愿者舌下芬太尼的药代动力学和耐受性：I期，开放标签单剂量研究
5. Safety and Efficacy of the Immunomodulatory Drug (IMiD) Lenalidomide in Patients with Lymphoma: Development of RU051417I - Phase I/II Open-Label Study of R-ICE (Rituximab-Ifosfamide-Carboplatin-Etoposide) with Lenalidomide [R2-ICE] in Patients with First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma (DLBCL). [D] . Kasi, Pashtoon Murtaza. 2018

机译：免疫调节药物来那度胺在淋巴瘤患者中的安全性和有效性：RU051417I-R-ICE（利妥昔单抗-异环磷酰胺-卡铂-依托泊苷）与来那度胺[R2-ICE]的I / II期开放标签研究的进展初次复发/原发性难治性弥漫性大B细胞淋巴瘤（DLBCL）。
6. Original article: Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with febuxostat in adults with gout: a phase IIa open-label study [O] . Roy Fleischmann, Peter Winkle, Jesse Hall, 2018

机译：原始文章：Verinurad联合非布索坦在成人痛风中的药效学和药代动力学作用及安全性：IIa期开放标签研究
7. Response to: ‘Correspondence on ‘Variants in urate transporters, ADH1B, GCKR and MEPE genes associated with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank’’ by Takei et al [O] . Gabriela Sandoval-Plata, Kevin Morgan, Abhishek Abhishek 2021

机译：响应于：呼吸转运蛋白，ADH1b，GCKR和MEPE基因对与无症状的高葡萄瘤转变为痛风的影响：使用来自英国Biobank''的数据的第一个痛风与无症状高温血症GWAS的结果，使用来自英国Biobank''的无症状高温血症GWA的结果

Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a open-label study

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