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Detailed classification of swimming paths in the Morris Water Maze: multiple strategies within one trial

机译:莫里斯水迷宫中游泳路径的详细分类:一项试验中的多种策略

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摘要

The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representing different animal strategies. However, these approaches typically consider trajectories as a whole, and as a consequence they assign one full trajectory to one class, whereas animals often switch between these strategies, and their corresponding classes, within a single trial. To this end, we take a different approach: we look for segments of diverse animal behaviour within one trial and employ a semi-automated classification method for identifying the various strategies exhibited by the animals within a trial. Our method allows us to reveal significant and systematic differences in the exploration strategies of two animal groups (stressed, non-stressed), that would be unobserved by earlier methods.
机译:莫里斯水迷宫在研究啮齿类动物的空间学习中被广泛使用。莫里斯水迷宫中动物的经典性能指标包括逃生潜伏期和到平台的累计距离。其他方法侧重于将轨迹模式分类为代表不同动物策略的定型类。但是,这些方法通常将轨迹视为一个整体,因此,它们将一个完整的轨迹分配给一个类别,而动物通常在一次试验中在这些策略及其对应的类别之间切换。为此,我们采用了不同的方法:我们在一项试验中寻找动物行为的不同部分,并采用半自动分类方法来识别试验中动物表现出的各种策略。我们的方法使我们能够揭示两种动物(有压力的,无压力的)动物在探索策略上的重大系统性差异,这是早期方法所无法观察到的。

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