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External-beam partial breast irradiation in a supine versus prone position after breast-conserving surgery for Chinese breast cancer patients

机译:中国乳腺癌患者保乳手术后仰卧位与俯卧位外照射

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摘要

To investigate the differences in target volumes and dosimetric parameters between the supine and prone positions for external-beam partial breast irradiation (EB-PBI) after breast-conserving surgery (BCS) for Chinese breast cancer patients, thirty breast cancer patients who underwent three-dimensional conformal radiation therapy (3DCRT) EB-PBI after BCS were enrolled. Supine and prone scan sets were acquired during free breathing for all patients. Target volumes and organs at risk (OARs) including the heart, ipsilateral lung and bilateral breast were contoured by the same radiation oncologist. For each patient, supine and prone EB-PBI plans were generated based on the same planning criteria. The clinical target volume (CTV) and planning target volume (PTV) in the prone position were significantly greater than those in the supine position (P = 0.003, 0.004, respectively). A 0.95 Gy reduction in the mean dose (Dmean) to the heart (P = 0.000) was apparent in the supine position compared to the prone position. The Dmean to the ipsilateral lung was significantly lower in the prone position than in the supine position (1.59 Gy vs. 1.72 Gy, P = 0.029). Therefore, for Chinese breast cancer patients, carrying out 3DCRT EB-PBI in the prone position during free breathing is feasible.
机译:为了研究中国乳腺癌患者在进行保乳手术(BCS)后的仰卧位和俯卧位之间的目标量和剂量参数之间的差异,这些患者接受保乳手术(BCS),其中30例接受了三纳入BCS后的三维适形放射治疗(3DCRT)EB-PBI。所有患者在自由呼吸期间均采集仰卧和俯卧扫描集。由同一位放射肿瘤科医生勾画出目标体积和包括心脏,同侧肺和双侧乳房在内的高危器官(OAR)。对于每位患者,均基于相同的计划标准制定了仰卧和俯卧EB-PBI计划。俯卧位的临床目标体积(CTV)和计划目标体积(PTV)显着大于仰卧位(P = 0.003,0.004)。与俯卧位相比,仰卧位的平均剂量(Dmean)降低了0.95 Gy(P = 0.000)。俯卧位到同侧肺的Dmean显着低于仰卧位(1.59 Gy对1.72 Gy,P = 0.029)。因此,对于中国乳腺癌患者,在自由呼吸期间在俯卧位进行3DCRT EB-PBI是可行的。

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