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Electric moulding of dispersed lipid nanotubes into a nanofluidic device

机译:将分散的脂质纳米管电铸成纳米流体装置

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摘要

Hydrophilic nanotubes formed by lipid molecules have potential applications as platforms for chemical or biological events occurring in an attolitre volume inside a hollow cylinder. Here, we have integrated the lipid nanotubes (LNTs) by applying an AC electric field via plug-in electrode needles placed above a substrate. The off-chip assembly method has the on-demand adjustability of an electrode configuration, enabling the dispersed LNT to be electrically moulded into a separate film of parallel LNT arrays in one-step. The fluorescence resonance energy transfer technique as well as the digital microscopy visualised the overall filling of gold nanoparticles up to the inner capacity of an LNT film by capillary action, thereby showing the potential of this flexible film for use as a high-throughput nanofluidic device where not only is the endo-signalling and product in each LNT multiplied but also the encapsulated objects are efficiently transported and reacted.
机译:由脂质分子形成的亲水性纳米管具有潜在的应用前景,可作为发生在中空圆柱体内部容积中的化学或生物事件的平台。在这里,我们通过放置在基板上方的插入式电极针施加交流电场来整合脂质纳米管(LNT)。芯片外组装方法具有电极配置的按需可调性,使分散的LNT可以一步一步地电铸成平行LNT阵列的单独膜。荧光共振能量转移技术以及数字显微镜通过毛细作用可视化了金纳米颗粒的整体填充量,直至LNT膜的内部容量,从而显示出这种柔性膜作为高通量纳米流体装置的潜力。不仅使每个LNT中的内信号传递和乘积成倍增加,而且封装的物体也得到了有效的运输和反应。

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