New α-glucosidase inhibitors from marine algae-derived Streptomyces sp. OUCMDZ-3434

摘要

Wailupemycins H (>1) and I (>2) with a new skeleton coupled two 6-(2-phenylnaphthalene-1-yl)pyrane-2-one nuclei to a –CH2– linkage were identified from the culture of Streptomyces sp. OUCMDZ-3434 associated with the marine algae, Enteromorpha prolifera. Compounds >1 and >2 are two new α-glucosidase inhibitors with the Ki/IC50 values of 16.8/19.7 and 6.0/8.3 μM, respectively. In addition, the absolute configurations of wailupemycins D (>3) and E (>4) are also resolved in this paper for the first time.