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Δ9-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits

机译：Δ9-四氢大麻酚衍生物负载的纳米制剂可降低血压正常兔的眼压

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PurposeΔ⁹-Tetrahydrocannabinol-valine-hemisuccinate, a hydrophilic prodrug of Δ⁹-tetrahydrocannabinol, synthesized with the aim of improving the ocular bioavailability of the parent molecule, was investigated in a lipid-based nanoparticle dosage form for ocular delivery.

机译：目的为了改善母体分子的眼生物利用度而合成的Δ^{9 -四氢大麻酚的亲水性前体药物Δ^{9 -四氢大麻酚-缬氨酸-半琥珀酸酯。用于眼部递送的基于脂质的纳米颗粒剂型。}}

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期刊名称 Translational Vision Science Technology
作者
Pranjal S. Taskar; Akash Patil; Prit Lakhani; Eman Ashour; Waseem Gul; Mahmoud A. ElSohly; Brian Murphy; Soumyajit Majumdar;
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作者单位

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年(卷),期 -1(8),5
年度 -1
页码 15
总页数 19
原文格式 PDF
正文语种
中图分类眼科学 ;
关键词
glaucoma tetrahydrocannabinol solid lipid nanoparticles intraocular pressure normotensive;

机译：青光眼;四氢大麻酚;固体脂质纳米颗粒;眼压;血压正常;

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专利

1. Reduction of intraocular pressure by SHP639, a novel C-type natriuretic peptide analog, and its exposure in aqueous humor of normotensive Dutch Belted rabbits and beagle dogs [J] . Savinainen Anneli, Prusakiewicz Jeffery J., Oswald Justine, Investigative ophthalmology & visual science . 2018 ,第9期

机译：通过SHP639降低眼压，一种新型C型利钠肽类似物，及其在正常荷兰腰带兔和比格犬的幽默中的暴露
2. Reduction of intraocular pressure by SHP639, a novel C-type natriuretic peptide analog, and its exposure in aqueous humor of normotensive Dutch Belted rabbits and beagle dogs [J] . Savinainen Anneli, Prusakiewicz Jeffery J., Oswald Justine, Investigative ophthalmology & visual science . 2018 ,第9期

机译：通过SHP639降低眼压，一种新型C型利钠肽类似物，及其在正常荷兰腰带兔和比格犬的幽默中的暴露
3. A pilot study on the novel effect of Neu-P11 on reducing the intraocular pressure in normotensive rabbits [J] . Shou-min Xi, Ping-yuan Gong, Shi-peng Li, African Journal of Pharmacy and Pharmacology . 2013 ,第44期

机译：Neu-P11降低血压正常兔眼压的新作用的初步研究
4. Topical Application of Melatonin Analogue Neu-P11 Reduces Intraocular Pressure in Normotensive Rabbit [C] . Xi Shou-min, Li San-qiang, Yin Wei-dong Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：褪黑素类似物Neu-P11的局部应用可降低血压正常兔的眼压
5. Long Term Intraocular Pressure (IOP) Lowering Effect of Femtosecond Laser Assisted Cataract Surgery (FLACS) Versus Conventional Phacoemulsification (PE) [D] . Ataei, Yasaman. 2020

机译：长期眼内压（IOP）对飞秒激光辅助白内障手术（FLACS）对常规沉默乳化的降低效果（PE）
6. Oral Omega-3 Supplementation Lowers Intraocular Pressure in Normotensive Adults [O] . Laura Elizabeth Downie, Algis Jonas Vingrys -1

机译：口服Omega-3补充剂可降低血压正常成人的眼压
7. Intraocular pressure lowering activities of endogenous cannabinoids, and their uptake and enzyme hydrolysis inhibitors in normotensive rabbits (Endogeenisten kannabinoidien ja niiden metabolian inhibiittorien vaikutukset kaniinien silmänpaineeseen) [O] . Laine Krista 100

机译：内源性大麻素及其代谢抑制剂对兔眼压的影响（内源性大麻素的降眼压活性）

Δ9-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits

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