Purpose: Melatonin is involved in regulation of intraocular pressure (IOP). In this study, we evaluated the effect of melatonin and its agonist, Neu-P11, on IOP in ocular normotensive rabbit eyes. Material and Methods: A multiple-dose (10-14mol/L ~ 10-5 mol/L, 10µl) study was performed in 30 male New Zealand white rabbits. Melatonin or Neu-P11 was applied topically, and IOP was measured for 7 hours and before experiment without any treatment as resting IOP. Results: Resting IOP was 20.65 ± 3.80mmHg valued at 100%. Topical application of melatonin or Neu-P11 produced dose-dependent reduction in IOP. Moreover, when the dose exceeded 10-9mol/L, Neu-P11 treatment group produced more significant decline in IOP compared with melatonin treatment group (P
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