Energy landscapes as a tool to integrate GPCR structure dynamics and function

摘要

G protein coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiologic responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are beginning to shed light on the molecular basis of this versatility. We use energy landscapes to conceptualize the link between structure and function.