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Targeting cancer cell-specific RNA interference by siRNA delivery using a complex carrier of affibody-displaying bio-nanocapsules and liposomes

机译：通过具有仿生展示生物纳米胶囊和脂质体的复杂载体通过siRNA递送靶向癌细胞特异性RNA干扰

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摘要

BackgroundSmall interfering RNA (siRNA) has attracted attention in the field of nucleic acid medicine as a RNA interference (RNAi) application that leads to gene silencing due to specific messenger RNA (mRNA) destruction. However, since siRNA is unstable in blood and unable to cross the cell membrane, encapsulation of siRNA into a carrier is required.

机译：背景技术小干扰RNA（siRNA）在核酸医学领域引起了人们的关注，因为RNA干扰（RNAi）应用由于特定的信使RNA（mRNA）破坏而导致基因沉默。然而，由于siRNA在血液中不稳定并且不能穿过细胞膜，因此需要将siRNA封装到载体中。

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期刊名称 Journal of Nanobiotechnology
作者
Yuya Nishimura; Hiroaki Mieda; Jun Ishii; Chiaki Ogino; Toshinobu Fujiwara; Akihiko Kondo;
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作者单位

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年(卷),期 2013(11),-1
年度 2013
页码 19
总页数 9
原文格式 PDF
正文语种
中图分类生物学;
关键词
RNA interference siRNA Hepatitis B virus Bio-nanocapsule Affibody HER2;

机译：RNA干扰;siRNA;乙型肝炎病毒;生物纳米粒;Affibody;HER2;

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专利

1. Targeting cancer cell-specific RNA interference by siRNA delivery using a complex carrier of affibody-displaying bio-nanocapsules and liposomes [J] . Yuya Nishimura, Hiroaki Mieda, Jun Ishii, Journal of Nanobiotechnology . 2013,第1期

机译：使用affibody展示生物纳米胶囊和脂质体的复杂载体通过siRNA递送靶向癌细胞特异性RNA干扰
2. Complex carriers of affibody-displaying bio-nanocapsules and composition-varied liposomes for HER2-expressing breast cancer cell-specific protein delivery [J] . NishimuraY., IshiiJ., OkazakiF., Journal of drug targeting . 2012,第10期

机译：用于显示HER2的乳腺癌细胞特异性蛋白质递送的亲和力展示生物纳米胶囊和成分可变脂质体的复杂载体
3. PEGylated DC-Chol/DOPE cationic liposomes containing KSP siRNA as a systemic siRNA delivery Carrier for ovarian cancer therapy [J] . Jinju Lee, Hyung Jun Ahn Biochemical and Biophysical Research Communications . 2018,第3期

机译：PEG化的DC-CHOL /掺杂阳离子脂质体含有KSP siRNA作为卵巢癌治疗的全身siRNA递送载体
4. Fabrication of polyvalent therapeutic RNA nanoparticles for specific delivery of siRNA, ribozyme and drugs to targeted cells for cancer therapy [C] . Yi Shu, Shu Dan, Diao Zhijuan, Life Science Systems and Applications Workshop, 2009. LiSSA 2009 . 2009

机译：多价治疗性RNA纳米粒子的制备，用于将siRNA，核酶和药物特异性递送至靶向细胞以进行癌症治疗
5. Development of Targeted, Polymeric Delivery Vehicles for Camptothecin and siRNA via Boronic Acid-Diol Complexation. [D] . Han, Han. 2013

机译：喜树碱和siRNA通过硼酸-二元醇络合的靶向，聚合物递送载体的开发。
6. Targeting HPV‐infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine [O] . Rachel M. Levine, Christina V. Dinh, Michael A. Harris, 2016

机译：用包裹siRNA的PEG化脂质体靶向HPV感染的宫颈癌细胞以及siRNA与聚乙烯亚胺络合的作用
7. Targeting cancer cell-specific RNA interference by siRNA delivery using a complex carrier of affibody-displaying bio-nanocapsules and liposomes [O] . Yuya Nishimura, Hiroaki Mieda, Jun Ishii, 2013

机译：通过具有仿生展示生物纳米胶囊和脂质体的复杂载体通过siRNA递送靶向癌细胞特异性RNA干扰

Targeting cancer cell-specific RNA interference by siRNA delivery using a complex carrier of affibody-displaying bio-nanocapsules and liposomes

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