Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice

机译：Wnt5a是斑马鱼和小鼠正常肾脏发育所必需的

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BackgroundWnt5a is important for the development of various organs and postnatal cellular function. Little is known, however, about the role of Wnt5a in kidney development, although WNT5A mutations were identified in patients with Robinow syndrome, a genetic disease which includes developmental defects in kidneys. Our goal in this study was to determine the role of Wnt5a in kidney development.

机译：背景Wnt5a对于各种器官的发育和产后细胞功能很重要。然而，尽管Wnt5a在肾脏发育中的遗传病Robinow综合征患者中发现了WNT5A突变，但对Wnt5a在肾脏发育中的作用知之甚少。我们在这项研究中的目标是确定Wnt5a在肾脏发育中的作用。

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期刊名称 Nephron. Experimental Nephrology
作者
Liwei Huang; An Xiao; Soo Young Choi; Quane Kan; Weibin Zhou; Maria F. Chacon-Heszele; Yun Kyoung Ryu; Sarah McKenna; Xiaofeng Zuo; Rejji Kuruvilla; Joshua H. Lipschutz;
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年(卷),期 -1(128),0
年度 -1
页码 80–88
总页数 15
原文格式 PDF
正文语种
中图分类泌尿科学（泌尿生殖系疾病）;小儿泌尿科学;肾疾病;
关键词
Wnt5a Kidney development Pronephros Mesonephros Metanephros;

机译：Wnt5a;肾脏发育;前肾;中肾;后肾;

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专利

1. Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice [J] . Liwei Huang, An Xiao, Soo Young Choi, Nephron . 2014,第1a2期

机译：Wnt5a是斑马鱼和小鼠正常肾脏发育所必需的
2. Il-10 deficient mice express IFN-gamma mRNA and clear Leptospira interrogans from their kidneys more rapidly than normal C57BL/6 mice [J] . Devlin Amy A., Halvorsen Priya J., Miller Jennifer C., Immunobiology: Zeitschrift fur Immunitatsforschung . 2017,第5期

机译：IL-10缺乏小鼠表达IFN-Gamma mRNA，并从其肾脏透明leptospira interrogans比正常的C57BL / 6小鼠更快
3. Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development. [J] . Dekel B, Amariglio N, Kaminski N, Journal of the American Society of Nephrology: JASN . 2002,第4期

机译：将人间肾移植入并分化为功能成熟的肾后，其基因表达谱与正常人肾发育相似。
4. Elevation of antioxidants in the kidneys of mice by low-dose irradiation and its effect on Fe~(3+)-NTA-induced kidney damage [C] . T. Nomur, K. Yamaoka, K. Sakaia International Symposium of Radiation and Homeostasis . 2002

机译：低剂量辐照肾脏浸润剂的抗氧化剂及其对Fe〜（3 +） - NTA诱发的肾脏损伤的影响
5. Scaling up to Study Kidney Development: Using the Zebrafish as a Highthroughput Model to Identify Novel Genetic Regulators [D] . ?Drummond, Bridgette E. 2019

机译：扩大研究肾发展：使用斑马鱼作为高吞吐量模型，以识别新型遗传调节因素
6. Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish [O] . Jade Li, Zhaoxia Sun 2011

机译：麒麟对于斑马鱼的纤毛组装和正常肾脏发育至关重要
7. Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice [O] . Liwei Huang, An Xiao, Soo Young Choi, 2014

机译：Wnt5a是斑马鱼和小鼠正常肾脏发育所必需的
8. Visualizing Normal and Defective Bone Development in Zebrafish Embryos Using theFluorescent Chromophore Calcein [R] . Du, S. J., Frenkel, V., Kindschi, G. A., 2001

机译：使用荧光发色团Calcein可视化斑马鱼胚胎的正常和缺陷骨发育

Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice

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