The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge

摘要

BackgroundThe recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Pegylated arginine deiminase (ADI-PEG20) is a bacterial enzyme used to deplete circulating arginine.