Acute Kidney Injury in Patients Treated with Vancomycin and Piperacillin-Tazobactam: A Retrospective Cohort Analysis

摘要

BACKGROUNDEmpiric antimicrobial therapy often consists of the combination of gram-positive coverage with vancomycin (VAN) and gram-negative coverage, specifically an antipseudomonal beta-lactam such as piperacillin-tazobactam (PTZ). Nephrotoxicity is commonly associated with VAN therapy; however, recent reports show higher nephrotoxicity rates among patients treated with the combination of VAN and PTZ.