Antibodies to Plasmodium falciparum and Plasmodium vivax Merozoite Surface Protein 5 in Indonesia: Species-Specific and Cross-Reactive Responses

摘要

BackgroundMerozoite surface protein (MSP) 5 is a candidate antigen for a malaria vaccine. In cross-sectional and longitudinal studies, we measured MSP5 antibody responses in Papuans with acute Plasmodium falciparum malaria, Plasmodium vivax malaria, and mixed P. falciparum and P. vivax malaria and in those with past exposure.