A Prospective Assessment of the Y402H Variant in Complement Factor H Genetic Variants in C-reactive Protein and Risk of Age-Related Macular Degeneration in Men

摘要

Background:Two biologically related factors, complement factor H (CFH) and C-reactive protein (CRP) have been associated with age-related macular degeneration (AMD). The Y402H variant of CFH is located within the binding site of CFH for CRP. Although plasma CRP levels have been related to AMD, and plasma CRP levels are partly determined by genetic variation, there is no information on whether genetic variants in CRP are associated with AMD.