mTOR Inhibition Promotes TTF1-Dependent Redifferentiation and Restores Iodine Uptake in Thyroid Carcinoma Cell Lines

机译：mTOR抑制可促进TTF1依赖性再分化并恢复甲状腺癌细胞系中的碘摄取。

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Concept:Redifferentiation of thyroid carcinoma cells has the potential to increase the efficacy of radioactive iodine therapy in treatment-refractory, nonmedullary thyroid carcinoma (TC), leading to an improved disease outcome. Mammalian target of rapamycin (mTOR) is a key regulator of cell fate affecting survival and differentiation, with autophagy and inflammation as prominent downstream pathways.

机译：概念：甲状腺癌细胞的再分化可能增加放射性碘疗法在难治性非髓样甲状腺癌（TC）中的疗效，从而改善疾病的预后。雷帕霉素的哺乳动物靶标（mTOR）是影响存活和分化的细胞命运的关键调节剂，自噬和炎症是主要的下游途径。

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期刊名称 The Journal of Clinical Endocrinology and Metabolism
作者
Theo S. Plantinga; Bas Heinhuis; Danny Gerrits; Mihai G. Netea; Leo A. B. Joosten; Ad R. M. M. Hermus; Wim J. G. Oyen; Rebecca E. Schweppe; Bryan R. Haugen; Otto C. Boerman; Johannes W. A. Smit; Romana T. Netea-Maier;
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年(卷),期 -1(99),7
年度 -1
页码 E1368–E1375
总页数 12
原文格式 PDF
正文语种
中图分类基础医学;
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1. mTOR Inhibition Promotes TTF1-Dependent Redifferentiation and Restores Iodine Uptake in Thyroid Carcinoma Cell Lines [J] . Theo S. Plantinga, Bas Heinhuis, Danny Gerrits, The journal of clinical endocrinology and metabolism . 2014,第7期

机译：mTOR抑制促进甲状腺癌细胞系中TTF1依赖性再分化并恢复碘摄取。
2. mTOR Inhibition Promotes TTF1-Dependent Redifferentiation and Restores Iodine Uptake in Thyroid Carcinoma Cell Lines [J] . Theo S. Plantinga, Bas Heinhuis, Danny Gerrits, The journal of clinical endocrinology and metabolism . 2014,第7期

机译：mTOR抑制促进甲状腺癌细胞系中TTF1依赖性再分化并恢复碘摄取。
3. Epigenetic Modifications in Thyroid Cancer Cells Restore NIS and Radio-Iodine Uptake and Promote Cell Death [J] . Sabine W?chter, Alexander I. Damanakis, Moritz Elxnat, Journal of Clinical Medicine . 2018,第4期

机译：甲状腺癌细胞中的表观遗传修饰可恢复NIS和放射性碘的摄取并促进细胞死亡
4. Cationic polystyrene nanosphere induces autophagy through inhibition of the Akt/mTOR and activation of the AMPK signaling pathways in macrophage and epithelial cells [C] . Hui-Wen Chiu, Tian Xia, Jui-Chen Tsai, Annual NSTI nanotechnology conference and expo . 2013

机译：阳离子聚苯乙烯纳米球通过抑制Akt / mTOR和激活巨噬细胞和上皮细胞中的AMPK信号通路来诱导自噬
5. Inhibition of compensatory survival and proliferative pathway activation induced by mtor inhibition in renal cell carcinoma. [D] . Bailey, Sean Thomas. 2014

机译：抑制mtor抑制在肾细胞癌中诱导的代偿性存活和增殖途径激活。
6. Epigenetic Modifications in Thyroid Cancer Cells Restore NIS and Radio-Iodine Uptake and Promote Cell Death [O] . Sabine Wächter, Alexander I. Damanakis, Moritz Elxnat, 2018

机译：甲状腺癌细胞中的表观遗传修饰可恢复NIS和放射性碘的摄取并促进细胞死亡
7. Reverse Transcriptase Inhibitors Down-Regulate Cell Proliferationin Vitroandin Vivoand Restore Thyrotropin Signaling and Iodine Uptake in Human Thyroid Anaplastic Carcinoma [O] . Matteo Landriscina, Annarita Fabiano, Settimia Altamura, 2005

机译：逆转转录酶抑制剂下调细胞增殖蛋白体内体内体内培养素替代甲状腺激素信号传导和碘摄取人甲状腺血管骨膜癌

mTOR Inhibition Promotes TTF1-Dependent Redifferentiation and Restores Iodine Uptake in Thyroid Carcinoma Cell Lines

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