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Impact of Patient Factors on Recurrence Risk and Time Dependency of Oxaliplatin Benefit in Patients With Colon Cancer: Analysis From Modern-Era Adjuvant Studies in the Adjuvant Colon Cancer End Points (ACCENT) Database

机译：患者因素对结肠癌患者复发风险和奥沙利铂获益时间依赖性的影响：佐剂结肠癌终点数据库（ACCENT）中现代时代佐剂研究的分析

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PurposeFluorouracil plus leucovorin (FU + LV) adjuvant chemotherapy reduced the risk of recurrence and death across all time points in a pooled analysis of 20,898 patients with colon cancer from 18 randomized studies. The impact of oxaliplatin added to FU + LV on the time course of recurrence and survival remains unknown.

机译：目的通过对18项随机研究的20898例结肠癌患者进行汇总分析，氟尿嘧啶联合亚叶酸（FU + LV）辅助化疗可降低所有时间点的复发和死亡风险。将奥沙利铂添加至FU + LV对复发和生存时间的影响尚不清楚。

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期刊名称 Journal of Clinical Oncology
作者
Manish A. Shah; Lindsay A. Renfro; Carmen J. Allegra; Thierry André; Aimery de Gramont; Hans-Joachim Schmoll; Daniel G. Haller; Steven R. Alberts; Greg Yothers; Daniel J. Sargent;
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年(卷),期 -1(34),8
年度 -1
页码 843–853
总页数 14
原文格式 PDF
正文语种
中图分类肿瘤学;
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专利

1. Impact of Patient Factors on Recurrence Risk and Time Dependency of Oxaliplatin Benefit in Patients With Colon Cancer: Analysis From Modern-Era Adjuvant Studies in the Adjuvant Colon Cancer End Points (ACCENT) Database [J] . Shah Manish A., Renfro Lindsay A., Allegra Carmen J., Journal of Clinical Oncology . 2016,第8期

机译：患者因素对结肠癌患者复发风险和奥沙利铂获益时间依赖性的影响：佐剂结肠癌终点数据库（ACCENT）中现代时代佐剂研究的分析
2. Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: Subgroup analyses of the multicenter international study of oxaliplatin, fluorouracil, and leucovorin in the adjuvant treatment of colon cancer trial [J] . TournigandC., AndréT., BonnetainF., Journal of Clinical Oncology . 2012,第27期

机译：氟尿嘧啶和奥沙利铂辅助治疗II期结肠癌和老年患者（年龄在70至75岁之间）：国际多中心研究奥沙利铂，氟尿嘧啶和亚叶酸钙在结肠癌辅助治疗中的亚组分析
3. Irinotecan and Oxaliplatin Might Provide Equal Benefit as Adjuvant Chemotherapy for Patients with Resectable Synchronous Colon Cancer and Liver-confined Metastases: A Nationwide Database Study [J] . Liang Yi-Hsin, Shao Yu-Yun, Chen Ho-Min, Anticancer Research: International Journal of Cancer Research and Treatment . 2017,第12期

机译：Irinotecan和Oxaliplatin可以为可重型同步结肠癌和肝限局限性转移患者提供平等的益处，辅助化疗：全国数据库研究
4. Adjuvant Chemotherapy Should Not Routinely Be Recommended to Patients with Stage II Colon Cancers that Manifest Microsatellite Instability [C] . Sigurdis Haraldsdottir, Richard M. Goldberg Gastrointestinal Cancers Symposium . 2014

机译：不应常规向患有阶段结肠癌的患者常规的辅助化学疗法，表明微卫星不稳定性
5. Adherence to adjuvant chemotherapy and post-treatment surveillance in a large community-based cohort of patients with colon cancer. [D] . Hu, Chung-Yuan. 2010

机译：在结肠癌患者的大型社区队列中坚持辅助化疗和治疗后监测。
6. Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence following adjuvant treatment: results of an ACCENT pooled analysis of seven studies [O] . J. Taieb, Q. Shi, L. Pederson, -1

机译：微卫星不稳定性和/或不匹配修复缺乏阶段III结肠癌患者的预后疾病复发后辅助治疗方法：七项研究的口音汇总分析结果
7. Irinotecan and Oxaliplatin Might Provide Equal Benefit as Adjuvant Chemotherapy for Patients with Resectable Synchronous Colon Cancer and Liver-confined Metastases: A Nationwide Database Study [O] . 2017

机译：Irinotecan和Oxaliplatin可以为辅助化疗提供平等的益处，用于可重型同步结肠癌和肝限局限性转移患者：全国范围内的数据库研究

Impact of Patient Factors on Recurrence Risk and Time Dependency of Oxaliplatin Benefit in Patients With Colon Cancer: Analysis From Modern-Era Adjuvant Studies in the Adjuvant Colon Cancer End Points (ACCENT) Database

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