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Evaluation of Ricinine a Ricin Biomarker from a Non-Lethal Castor Bean Ingestion

机译:非致命性蓖麻子摄入中的蓖麻毒素生物标志物蓖麻碱的评估

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摘要

A case of attempted suicide of a 58-year-old man using castor beans is presented. The patient came to the emergency room complaining of nausea, vomiting and diarrhea for nine hours following ingestion of six castor beans. Urine samples were taken throughout the hospital stay and submitted to the Centers for Disease Control and Prevention for analysis of ricinine, a castor bean component. The samples were found to be positive for ricinine with a maximum concentration of 674 µg/g-creatinine excreted around 23 hours post-exposure. Subsequent samples demonstrated lower ricinine concentrations with the final sample taken at 62 hours post-exposure at a concentration of 135 µg/g-creatinine of ricinine. The estimated urinary excretion half-life was around 15 hours and the recovery of ricinine in the urine over the three days was estimated to be less than 10%. The patient fully recovered with supportive care and was discharged from the hospital six days after admission.
机译:介绍了一个使用蓖麻子自杀未遂的58岁男子的案例。进食六个蓖麻子后,患者来到急诊室,抱怨了九个小时的恶心,呕吐和腹泻。在整个住院期间都采集了尿液样本,并将其送至疾病控制与预防中心进行蓖麻子碱蓖麻碱的分析。发现样品中的蓖麻碱呈阳性,在暴露后23小时左右排出的最大浓度为674 µg / g肌酐。随后的样品显示出较低的蓖麻碱浓度,而最终样品则在暴露后62小时以135 µg / g的蓖麻氨酸肌酐浓度采集。估计的尿排泄半衰期约为15小时,三天尿液中蓖麻碱的回收率估计不足10%。该患者在支持治疗下完全康复,入院六天后出院。

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