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Double-Blind Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102 a Neutralizing IL-1β Antibody in Patients With Type 2 Diabetes

机译：一项双盲随机研究评估了中性IL-1β抗体LY2189102皮下注射对2型糖尿病患者的血糖和抗炎作用

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摘要

OBJECTIVEInflammation is associated with pancreatic β-cell apoptosis and reduced insulin sensitivity. Literature suggests that interleukin (IL)-1β may contribute to the pathogenesis of type 2 diabetes mellitus (T2DM). This study aimed to determine the efficacy, safety, and tolerability of LY2189102, a neutralizing IL-1β antibody, in T2DM patients.

机译：目的炎症与胰腺β细胞凋亡和胰岛素敏感性降低有关。文献提示白介素（IL）-1β可能与2型糖尿病（T2DM）的发病机理有关。这项研究旨在确定中和性IL-1β抗体LY2189102在T2DM患者中的疗效，安全性和耐受性。

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期刊名称 Diabetes Care
作者
Joanne Sloan-Lancaster; Eyas Abu-Raddad; John Polzer; Jeffrey W. Miller; Joel C. Scherer; Andrea De Gaetano; Jolene K. Berg; William H. Landschulz;
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作者单位

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年(卷),期 2013(36),8
年度 2013
页码 2239–2246
总页数 8
原文格式 PDF
正文语种
中图分类护理学;
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专利

1. Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients With Type 2 Diabetes. [J] . Joanne Sloan-Lancaster, Eyas Abu-Raddad, John Polzer, Diabetes care . 2013,第8期

机译：一项双盲，随机研究评估了中性IL-1β抗体LY2189102皮下注射对2型糖尿病患者的血糖和抗炎作用。
2. Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients With Type 2 Diabetes. [J] . Joanne Sloan-Lancaster, Eyas Abu-Raddad, John Polzer, Diabetes care . 2013,第8期

机译：双盲，随机研究评估皮下Ly2189102，中和IL-1β抗体的血糖和抗炎作用，患有2型糖尿病患者。
3. A randomized, double-blind, placebo-controlled study on long-term efficacy and safety of ipragliflozin treatment in patients with type 2 diabetes mellitus and renal impairment: results of the Long-Term ASP1941 Safety Evaluation in Patients with Type 2 Diabetes with Renal Impairment (LANTERN) study [J] . Kashiwagi A., Takahashi H., Ishikawa H., Diabetes, obesity & metabolism . 2015,第2期

机译：一项关于伊格列净治疗2型糖尿病和肾功能不全患者的长期疗效和安全性的随机，双盲，安慰剂对照研究：对患有肾功能不全的2型糖尿病患者进行长期ASP1941安全性评估的结果（LANTERN）研究
4. Towards Prediction of Type 1 Diabetes Patients Who Fail to Achieve Glycemic Target [C] . Morten Hasselstr?m Jensen, Simon Cichosz, Ole Hejlesen, Medical Informatics Europe Conference . 2020

机译：朝向1型糖尿病患者的预测，所述糖尿病患者未能达到血糖目标
5. A randomized, open-label, intervention study to evaluate the effect of diet composition on weight gain in obese, type 2 diabetes patients receiving intensive insulin therapy. [D] . Villareal, Roland. 2008

机译：一项随机，开放标签，干预性研究，以评估饮食结构对接受强化胰岛素治疗的肥胖2型糖尿病患者体重增加的影响。
6. Evaluation of the Effect of an Aqueous Extract of Azadirachta indica (Neem) Leaves and Twigs on Glycemic Control Endothelial Dysfunction and Systemic Inflammation in Subjects with Type 2 Diabetes Mellitus – A Randomized Double-Blind Placebo-Controlled Clinical Study [O] . Usharani Pingali, Mohammed Abid Ali, Srinivas Gundagani, 2020

机译：评价azadirachta indaga（Neem）叶片和枝条对患有2型糖尿病患者血糖对照内皮功能障碍和全身炎症的影响的评价 - 随机双盲安慰剂对照临床研究
7. Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1 Antibody, in Patients With Type 2 Diabetes [O] . J. Sloan-Lancaster, E. Abu-Raddad, J. Polzer, 2013

机译：双盲，随机研究评估皮下LY2189102的血糖和抗炎作用，患有2型糖尿病患者中和IL-1抗体的血糖和抗炎作用

Double-Blind Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102 a Neutralizing IL-1β Antibody in Patients With Type 2 Diabetes

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