DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads

机译：DMRT1抑制使用一种新颖的基因操作方法诱导人类胎儿性腺的睾丸发育不全。

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STUDY QUESTIONDoes loss of DMRT1 in human fetal testis alter testicular development and result in testicular dysgenesis?

机译：研究问题人胎睾丸中DMRT1的丢失会改变睾丸发育并导致睾丸发育不良吗？

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期刊名称 Human Reproduction (Oxford England)
作者
Joni Macdonald; Karen R Kilcoyne; Richard M Sharpe; Áine Kavanagh; Richard A Anderson; Pamela Brown; Lee B Smith; Anne Jørgensen; Rod T Mitchell;
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作者单位

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年(卷),期 -1(33),11
年度 -1
页码 2107–2121
总页数 15
原文格式 PDF
正文语种
中图分类妇产科学;生理学;
关键词
human fetal testis gonadal development DMRT1 testicular dysgenesis sex differentiation miRNA;

机译：人胎睾丸;性腺发育;DMRT1;睾丸发育不全;性别分化;miRNA;

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专利

1. DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads [J] . Macdonald Joni, Kilcoyne Karen R., Sharpe Richard M., Human Reproduction . 2018,第11期

机译：使用新型遗传操作方法的DMRT1抑制诱导人胎儿性腺睾丸性妊娠功能
2. CRISPR/Cas9-mediated simultaneous knockout of Dmrt1 and Dmrt3 does not recapitulate the 46,XY gonadal dysgenesis observed in 9p24.3 deletion patients [J] . Masafumi Inui, Moe Tamano, Tomoko Kato, Biochemistry and Biophysics Reports . 2017,第2期

机译：CRISPR / Cas9介导的同时敲除Dmrt1和Dmrt3不能概括9p24.3缺失患者的46，XY性腺发育不良
3. The p.R92W variant of NR5A1/Nr5a1 induces testicular development of 46,XX gonads in humans, but not in mice: phenotypic comparison of human patients and mutation-induced mice [J] . Mami Miyado, Masafumi Inui, Maki Igarashi, Biology of Sex Differences . 2016,第1期

机译：NR5A1 / Nr5a1的p.R92W变体在人类而非小鼠中诱导46，XX性腺的睾丸发育：人类患者和突变诱导小鼠的表型比较
4. Visualisation of an nsPEF induced calcium wave using the genetically encoded calcium indicator GCaMP in U87 human glioblastoma cells [C] . Lynn Carr, Sylvia M. Bardet, Rodney P. OConnor Joint Meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association . 2018

机译：使用U87人胶质母细胞瘤细胞的遗传编码钙指示剂Gcamp的NSPEF诱导钙波的可视化
5. Epigenetic Mechanisms and Treatments of Fetal Alcohol Exposure-Induced Memory Impairment and Metabolic Dysregulation. [D] . Tunc-Ozcan, Elif. 2017

机译：胎儿酒精暴露引起的记忆障碍和代谢异常调节的表观遗传机制和治疗。
6. CRISPR/Cas9-mediated simultaneous knockout of Dmrt1 and Dmrt3 does not recapitulate the 46XY gonadal dysgenesis observed in 9p24.3 deletion patients [O] . Masafumi Inui, Moe Tamano, Tomoko Kato, 2017

机译：CRISPR / Cas9介导的同时敲除Dmrt1和Dmrt3不能概括9p24.3缺失患者的46XY性腺发育不良
7. DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads [O] . Joni Macdonald, Karen R Kilcoyne, Richard M Sharpe, 2018

机译：DMRT1抑制利用新型遗传操作方法诱导人胎儿性腺睾丸性妊娠功能

DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads

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