Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice

摘要

BackgroundEmerging evidence indicates that long-time use of multiple antibiotics can induce cognitive dysfunction via gut dysbiosis. Cefazolin is often used for 3 to 5 days to prevent perioperative infection. This study is to detect the impact of perioperative use of cefazolin on inflammatory responses and postoperative cognition.