Risk of Suicidal Behavior With Use of Efavirenz: Results from the Strategic Timing of Antiretroviral Treatment Trial

机译：使用依法韦仑引起自杀行为的风险：抗逆转录病毒治疗试验的战略时机结果

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BackgroundRandomized trials have shown increased risk of suicidality associated with efavirenz (EFV). The START (Strategic Timing of Antiretroviral Treatment) trial randomized treatment-naive human immunodeficiency virus (HIV)–positive adults with high CD4 cell counts to immediate vs deferred antiretroviral therapy (ART).

机译：背景随机试验显示与依非韦伦（EFV）相关的自杀倾向风险增加。 START（抗逆转录病毒治疗的战略时机）试验将具有高CD4细胞计数的未接受过治疗的人类免疫缺陷病毒（HIV）阳性成人随机分为即刻抗病毒治疗和延缓抗逆转录病毒治疗（ART）。

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期刊名称 Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
作者
Alejandro Arenas-Pinto; Birgit Grund; Shweta Sharma; Esteban Martinez; Nathan Cummins; Julie Fox; Karin L Klingman; Dalibor Sedlacek; Simon Collins; Patricia M Flynn; William M Chasanov; Eynat Kedem; Christine Katlama; Juan Sierra-Madero; Claudia Afonso; Pim Brouwers; David A Cooper;
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年(卷),期 -1(67),3
年度 -1
页码 420–429
总页数 10
原文格式 PDF
正文语种
中图分类免疫学;微生物学;病毒传染病;
关键词
HIV suicidal behavior efavirenz;

机译：HIV;自杀行为;依非韦伦;

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专利

1. Risk of Suicidal Behavior With Use of Efavirenz: Results from the Strategic Timing of Antiretroviral Treatment Trial [J] . Arenas-Pinto Alejandro, Grund Birgit, Sharma Shweta, Fortschritte der Physik . 2018,第3期

机译：使用efavirazenz的自杀行为风险：抗逆转录病毒治疗试验的战略时机的结果
2. Risk Factors for Low CD4(+) Count Recovery Despite Viral Suppression Among Participants Initiating Antiretroviral Treatment With CD4(+) Counts > 500 Cells/mm(3): Findings From the Strategic Timing of AntiRetroviral Therapy (START) Trial [J] . Boatman Jeffrey A., Baker Jason V., Emery Sean, JAIDS: Journal of acquired immune deficiency syndromes . 2019,第1期

机译：低CD4（+）计数恢复的危险因素尽管参与者在抗逆转录病毒治疗和CD4（+）计数> 500细胞/ mm（3）中的病毒抑制：来自抗逆转录病毒治疗（开始）试验的战略时机的调查结果
3. Prevalence of and risk factors for low bone mineral density in untreated HIV infection: a substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial [J] . Carr A., Grund B., Neuhaus J., HIV medicine . 2015,第Suppla1期

机译：未经治疗的HIV感染中骨矿物质密度低的患病率和危险因素：抗逆转录病毒疗法（START）试验的INSIGHT战略时机的子研究
4. The Two First-Line Recommended Antiretroviral Regimens for Naive HIV-Infected Patients: Efavirenz-Based Versus Lopinavir-Ritonavir-Based Haart [C] . R. Manfredi, L. Calza, F. Chiodo International AIDS Conference . 2004

机译：幼稚艾滋病毒感染患者的两种第一线推荐的抗逆转录病毒方案：efavirenz为基于Lopinavir-Ritonavir的HAART
5. Validation of a UPLC-MS/MS method for the simultaneous measurement of the antiretroviral drugs atazanavir, darunavir, efavirenz, etravirine, lopinavir, raltegravir, ritonavir from human plasma. [D] . Patel, Rutva. 2012

机译：用于从人血浆中同时测定抗逆转录病毒药物阿扎那韦，达鲁那韦，依非韦伦，依曲韦林，洛匹那韦，拉格列韦，利托那韦的UPLC-MS / MS方法的验证。
6. Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV‐Positive Participants in the START (Strategic Timing of Antiretroviral Treatment) Trial [O] . Jason V. Baker, Shweta Sharma, Amit C. Achhra, 2017

机译：在START（抗逆转录病毒治疗的战略时机）试验中HIV阳性参与者立即开始抗病毒治疗和延缓抗逆转录病毒治疗后心血管疾病危险因素的变化
7. Transmission risk behaviour at enrolment in participants in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial [O] . Rodger, A, Lampe, F, Grulich, A, 2015

机译：INSIGHT抗逆转录病毒治疗的战略时机（START）试验参与者的传播风险行为

Risk of Suicidal Behavior With Use of Efavirenz: Results from the Strategic Timing of Antiretroviral Treatment Trial

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