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Editors choice: A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia

机译：编辑精选：新型人类R25C-磷脂酰肌醇蛋白突变与钙循环和室性心律失常的超抑制有关

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摘要

AimsDepressed sarcoplasmic reticulum (SR) Ca²⁺ cycling, a universal characteristic of human and experimental heart failure, may be associated with genetic alterations in key Ca²⁺-handling proteins. In this study, we identified a novel PLN mutation (R25C) in dilated cardiomyopathy (DCM) and investigated its functional significance in cardiomyocyte Ca²⁺-handling and contractility.

机译：目的：抑郁的肌浆网Ca ^{2 + 循环是人类和实验性心力衰竭的普遍特征，可能与关键Ca ^{2 + 处理蛋白的遗传改变有关。在这项研究中，我们在扩张型心肌病（DCM）中鉴定了一个新的PLN突变（R25C），并研究了其在心肌细胞Ca ^{2 + 处理和收缩中的功能意义。}}}

著录项

期刊名称 Cardiovascular Research
作者
Guan-Sheng Liu; Ana Morales; Elizabeth Vafiadaki; Chi Keung Lam; Wen-Feng Cai; Kobra Haghighi; George Adly; Ray E. Hershberger; Evangelia G. Kranias;
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作者单位

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年(卷),期 -1(107),1
年度 -1
页码 164–174
总页数 11
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Dilated cardiomyopathy Calcium cycling Mutation;

机译：扩张型心肌病;钙循环;突变;

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专利

1. A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia [J] . Liu Guan-Sheng, Morales Ana, Vafiadaki Elizabeth, Cardiovascular Research . 2015,第1期

机译：一种新的人类R25C-phospholamban突变与钙循环和室性心律失常的超抑制有关
2. Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia [J] . Annukka Marjamaa, P?ivi Laitinen-Forsblom, Annukka M Lahtinen, BMC Medical Genetics . 2009,第1期

机译：类似于儿茶酚胺能性多形性室性心动过速的家族性室性心律失常中心脏钙循环基因突变的搜索
3. Calcium Channel Antagonism Reduces Exercise-Induced Ventricular Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia Patients with RyR2 Mutations. [J] . Swan H, Laitinen P, Kontula K, Journal of cardiovascular electrophysiology . 2005,第2期

机译：钙通道拮抗作用可降低运动型心室心律失常的儿茶酚胺能性多发性室性心动过速患者的RyR2突变。
4. Deviant Calcium Channels: Role in Ventricular Arrhythmias-A Computational Study on Human Ventricular Tissue [C] . G. Gulothungan, R. Malathi International conference on advanced computational and communication paradigms . 2018

机译：偏差钙通道：在心室心律失常中的作用 - 人类心室组织的计算研究
5. Abnormal calcium cycling as a mechanism for the initiation of cardiac arrhythmia: A simulation study in a ventricular myocyte model. [D] . Faber, Gregory Martin. 2007

机译：钙循环异常是引发心律不齐的机制：在心室肌细胞模型中的模拟研究。
6. Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia [O] . Annukka Marjamaa, Päivi Laitinen-Forsblom, Annukka M Lahtinen, 2009

机译：类似于儿茶酚胺能性多形性室性心动过速的家族性室性心律失常中心脏钙循环基因突变的搜索
7. A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia [O] . Guan-Sheng Liu, Ana Morales, Elizabeth Vafiadaki, 2015

机译：一种新的人R25C-磷蛋白突变与钙循环和心间心律失常的超级抑制有关

Editors choice: A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia

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