Introgression of the Brown Norway Renin Allele Onto the Dahl Salt-Sensitive Genetic Background Increases Cu/Zn SOD Expression in Cerebral Arteries

摘要

BackgroundNitric oxide (NO)-dependent vasodilation is impaired in middle cerebral arteries (MCas) from Dahl salt-sensitive (SS) rats that are fed normal salt (NS) diet, due to low plasma renin activity and chronic exposure to low plasma angiotensin II (aNG II) levels. NO-dependent vasodilator responses are rescued in MCas from Ren1-BN congenic rats, which have a 2.0 Mbp portion of Brown Norway (BN) chromosome 13 containing the renin gene introgressed onto the Dahl SS genetic background.