首页> 美国卫生研究院文献>Journal of Translational Medicine >Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling

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Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling

机译：右美托咪定可能通过抑制Toll样受体4核因子κB信号转导减轻大鼠原位自体肝移植后的急性肺损伤

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摘要

BackgroundTo investigate whether pretreatment with dexmedetomidine (Dex) has a protective effect against acute lung injury (ALI) in an orthotopic autologous liver transplantation (OALT) rat model and to explore the mechanisms responsible for the protective effect of Dex against lung injury.

机译：背景为了研究右美托咪定（Dex）预处理在原位自体肝移植（OALT）大鼠模型中是否对急性肺损伤（ALI）有保护作用，并探讨负责Dex对肺损伤的保护作用的机制。

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期刊名称 Journal of Translational Medicine
作者
Xinjin Chi; Xiaoxia Wei; Wanling Gao; Jianqiang Guan; Xiaofan Yu; Yiheng Wang; Xi Li; Jun Cai;
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作者单位

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年(卷),期 2015(13),-1
年度 2015
页码 190
总页数 8
原文格式 PDF
正文语种
中图分类医学史;
关键词
Liver transplantation Acute lung injury Toll-like receptor 4 Dexmedetomidine;

机译：肝移植;急性肺损伤;Toll样受体4;右美托咪定;

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专利

1. Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling [J] . Xinjin Chi, Xiaoxia Wei, Wanling Gao, Journal of Translational Medicine . 2015,第1期

机译：右美托咪定可能通过抑制Toll样受体4–核因子κB信号转导减轻大鼠原位自体肝移植后的急性肺损伤
2. Astragalus membranaceus and Salvia miltiorrhiza Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Rats by Regulating the Toll-Like Receptor 4/Nuclear Factor-Kappa B Signaling Pathway [J] . Li Qin, Hong-Ling Tan, Yu-Guo Wang, Evidence-based complementary and alternative medicine: eCAM . 2018,第7期

机译：黄芪和丹参通过调节Toll样受体4 /核因子-κB信号通路改善脂多糖诱导的大鼠急性肺损伤
3. Astragalus membranaceus and Salvia miltiorrhiza Ameliorate Lipopolysaccharide- Induced Acute Lung Injury in Rats by Regulating the Toll-Like Receptor 4/Nuclear Factor-Kappa B Signaling Pathway [J] . Qin Li, Tan Hong-Ling, Wang Yu-Guo, Evidence-based complementary and alternative medicine: eCAM . 2018,第1期

机译：Astragalus膜和Salvia Miltiorrhiza通过调节Toll样受体4 /核因子-Kappa B信号通路来改善脂多糖诱导的急性肺损伤
4. Activation of nuclear factor-kappa B (NF-kB) in alveolar macrophages and lung tissue of ventilated animals with acute lung injury. [C] . Acta pharmacologica sinica . 2002

机译：急性肺损伤通气动物肺泡巨噬细胞和肺组织中核因子-κB（NF-kB）的活化。
5. Signaling mechanism by which thromboxane receptor activation modulates interleukin-1[beta]-induced monocyte adhesion and nuclear factor [kappa]B-dependent gene expression in vascular smooth muscle cells [D] . Bayat, Hossein 2008

机译：血栓烷受体激活调节血管平滑肌细胞中白介素-1β诱导的单核细胞粘附和核因子κB依赖性基因表达的信号传导机制
6. Astragalus membranaceus and Salvia miltiorrhiza Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Rats by Regulating the Toll-Like Receptor 4/Nuclear Factor-Kappa B Signaling Pathway [O] . Li Qin, Hong-Ling Tan, Yu-Guo Wang, 2018

机译：黄芪和丹参通过调节Toll样受体4 /核因子-κB信号通路改善脂多糖诱导的大鼠急性肺损伤
7. Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling [O] . Xinjin Chi, Xiaoxia Wei, Wanling Gao, 2015

机译：右美托咪定可能通过抑制Toll样受体4–核因子κB信号转导减轻大鼠原位自体肝移植后的急性肺损伤

Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling

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