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Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients

机译：UDP-葡萄糖醛酸糖基转移酶多态性与霉酚酸酯在中国肾移植患者体内的药代动力学关系

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摘要

Aim:To evaluate the effects of UDP-glucuronosyltransferases (UGTs) polymorphisms on the pharmacokinetics of the immunosuppressant mycophenolate mofetil (MMF) in Chinese renal transplant recipients.

机译：目的：评估UDP-葡糖醛酸糖基转移酶（UGTs）多态性对中国肾移植受者免疫抑制剂霉酚酸酯（MMF）药代动力学的影响。

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期刊名称 Acta Pharmacologica Sinica
作者
Xiao-chun Xie; Jun Li; Hong-yang Wang; Hong-liang Li; Jing Liu; Qian Fu; Jia-wen Huang; Chen Zhu; Guo-ping Zhong; Xue-ding Wang; Ping-ping Sun; Min Huang; Chang-xi Wang; Jia-li Li;
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作者单位

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年(卷),期 2015(36),5
年度 2015
页码 644–650
总页数 7
原文格式 PDF
正文语种
中图分类药学;
关键词
renal transplantation immunosuppressant mycophenolate mofetil mycophenolic acid 7-O-MPA-glucuronide pharmacokinetics UDP-glucuronosyltransferases genetic polymorphisms;

机译：肾移植;免疫抑制剂;霉酚酸酯;霉酚酸;7-O-MPA-葡萄糖醛酸苷;药代动力学;UDP-葡萄糖醛酸转移酶;遗传多态性;

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专利

1. Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients [J] . Xiao-chun XIE, Jun LI, Hong-yang WANG, 中国药理学报：英文版 . 2015,第005期

机译：UDP-葡糖醛酸糖基转移酶多态性与中国肾移植患者霉酚酸酯代谢动力学的相关性
2. Influence of UDP-glucuronosyltransferase polymorphisms on mycophenolate mofetil-induced side effects in kidney transplant patients. [J] . Betonico GN, Abbud-Filho M, Goloni-Bertollo EM, Transplantation Proceedings . 2008,第3期

机译：UDP-葡糖醛酸糖基转移酶多态性对肾移植患者霉酚酸酯引起的副作用的影响。
3. Pharmacokinetic and metabolic investigations of mycophenolic acid in pediatric patients after renal transplantation: implications for therapeutic drug monitoring. German Study Group on Mycophenolate Mofetil Therapy in Pediatric Renal Transplant Recip [J] . Oellerich M, Shipkova M, Schutz E, Therapeutic Drug Monitoring . 2000,第1期

机译：儿科患者肾脏移植后麦考酚酸的药代动力学和代谢研究：对治疗药物监测的意义。德国霉酚酸酯治疗小儿肾脏移植方案的研究小组
4. ASSOCIATION OF CYP3A4 * 18B POLYMORPHISMS WITH THE PHARMACOKINETICS OF TACROLIMUS IN CHINESE RENAL TRANSPLANT RECIPIENTS [C] . Li Danying, Fang Yun, Teng Ruichen Progress on post-genome technologies and modern natural products . 2011

机译：CYP3A4 * 18B多态性与中国肾移植患者滑石M药代动力学的关系
5. Peripheral nerve regeneration in rat hind limb transplantation using FK 506 and mycophenolate mofetil immunosuppressive therapy [D] . Cottrell, Bradford Lee 2002

机译：FK 506和霉酚酸酯对大鼠后肢移植的周围神经再生免疫抑制治疗
6. Pharmacokinetics safety and efficacy of mycophenolate mofetil in combination with cirolimus or ciclosporin in renal transplant patients [O] . Mark D Pescovitz, Flavio Vincenti, Marquis Hart, 2007

机译：麦考酚酸酯联合西罗莫司或环孢素在肾移植患者中的药代动力学安全性和疗效
7. Pharmacokinetics of mycophenolic acid (MPA) and determinants of MPA free fraction in pediatric and adult renal transplant recipients. German Study group on Mycophenolate Mofetil Therapy in Pediatric Renal Transplant Recipients. [O] . L T Weber, M Shipkova, T Lamersdorf, 1998

机译：霉菌酸（MPA）的药代动力学和小儿和成人肾移植受者MPA自由分数的决定因素。德国研究组在儿科肾移植受体中的霉菌霉素治疗。

Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients

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