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Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL IL-6 PGE2 and MMP-13 expression

机译：去甲去甲胆碱通过降低RANKLIL-6PGE2和MMP-13的表达减轻佐剂性关节炎大鼠的关节破坏

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摘要

Aim:To explore the effects of norisoboldine (NOR), a major isoquinoline alkaloid in Radix Linderae, on joint destruction in rats with adjuvant-induced arthritis (AIA) and its underlying mechanisms.

机译：目的：探讨林丹中主要的异喹啉类生物碱去甲胆碱（NOR）对佐剂性关节炎（AIA）大鼠关节破坏的作用及其潜在机制。

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期刊名称 Acta Pharmacologica Sinica
作者
Zhi-feng Wei; Xiao-lan Jiao; Ting Wang; Qian Lu; Yu-feng Xia; Zheng-tao Wang; Qing-long Guo; Gui-xin Chou; Yue Dai;
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作者单位

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年(卷),期 2013(34),3
年度 2013
页码 403–413
总页数 11
原文格式 PDF
正文语种
中图分类药学;
关键词
norisoboldine dexamethasone rheumatoid arthritis adjuvant-induced arthritis joint destruction fibroblast-like synoviocyte receptor activator of nuclear factor κB ligand IL-6 PGE2 MMP-13 COX-2 p38/ERK/AKT/AP-1 pathway;

机译：去甲胆碱;地塞米松;类风湿性关节炎;佐剂性关节炎;关节破坏;成纤维样滑膜细胞;核因子κB配体的受体激活剂;IL-6;PGE2;MMP-13;COX-2;p38 / ERK / AKT / AP- 1路;

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专利

1. Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL, IL-6,PGE2, and MMP-13 expression [J] . Zhi-feng WEI, Xiao-lan JIAO, Ting WANG, 中国药理学报：英文版 . 2013,第003期

机译：去甲去甲胆碱通过降低RANKL，IL-6，PGE2和MMP-13的表达来减轻佐剂性关节炎大鼠的关节破坏
2. Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund's adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway [J] . Amany A. Azouz, Esraa Saleh, Ali A. Abo-Saif Saudi Pharmaceutical Journal . 2020,第9期

机译：Aliskiren，Tadalafil和Cinnamaldehyde缓解联合破坏生物标志物; MMP-3和RANKL;完全弗氏佐剂关节炎模型：下调IL-6 / JAK2 / Stat3信号通路
3. Intra-articular administration of tachykinin NK receptor antagonists reduces hyperalgesia and cartilage destruction in the inflammatory joint in rats with adjuvant-induced arthritis. [J] . Uematsu T, Sakai A, Ito H, European Journal of Pharmacology: An International Journal . 2011,第1a2期

机译：速激肽NK受体拮抗剂的关节内给药可减少佐剂诱发的关节炎大鼠的炎症痛觉过敏和软骨破坏。
4. Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model [C] . Xueding Wang, Justin Rajian, Xia Shao, Conference on photons plus ultrasound: imaging and sensing . 2014

机译：光声成像表征和治疗性关节炎的监测：佐剂诱发的关节炎大鼠模型的研究
5. A Peptide Comprising the Src-Interacting Domain of NADH Dehydrogenase Subunit 2 Alleviates Complete Freund's Adjuvant-Induced Allodynia in Rats. [D] . Barszczyk, Andrew. 2010

机译：包含NADH脱氢酶亚基2 Src相互作用域的肽减轻大鼠完全弗氏佐剂诱导的异常性疼痛。
6. Aliskiren tadalafil and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freunds adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway [O] . Amany A. Azouz, Esraa Saleh, Ali A. Abo-Saif 2020

机译：AliskirenTadalafil和Cinnamaldehyde缓解联合破坏生物标志物; MMP-3和RANKL;完全弗氏佐剂关节炎模型：下调IL-6 / JAK2 / Stat3信号通路
7. Identifying the preferable rheumatoid arthritis subgroups for intervention with the anti-RANKL antibody denosumab to reduce progression of joint destruction [O] . Yoshiya Tanaka, Satoshi Soen, Naoki Ishiguro, 2020

机译：鉴定抗rankl抗体Denosumab的干预的优选类风湿性关节炎亚组，以减少联合破坏的进展

Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL IL-6 PGE2 and MMP-13 expression

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