A novel hemostatic sealant composed of gelatin transglutaminase and thrombin effectively controls liver trauma-induced bleeding in dogs

摘要

Aim:A novel hemostatic sealant based on the in situ gel formation of gelatin catalyzed by thrombin and crosslinked by transglutaminase was designed. The aim of this study was to investigate the efficacy of the hemostatic sealant in control of bleeding caused by liver trauma in dogs.