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Benzbromarone an old uricosuric drug inhibits human fatty acid bindingprotein 4 in vitro and lowers the blood glucose level in db/dbmice

机译：苯溴马隆一种旧的尿酸排泄药物可抑制人体脂肪酸结合蛋白4在体外并降低血糖水平以db / db为单位老鼠

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摘要

Aim:Fatty acid-binding protein 4 (FABP4) plays an important role in maintaining glucose and lipid homeostasis. The aim of this study was to find new inhibitors of FABP4 for the treatment of type 2 diabetes.

机译：目的：脂肪酸结合蛋白4（FABP4）在维持葡萄糖和脂质体内平衡方面起着重要作用。这项研究的目的是寻找新的FABP4抑制剂来治疗2型糖尿病。

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期刊名称 Acta Pharmacologica Sinica
作者
Hai-yan Cai; Ting Wang; Jian-chun Zhao; Peng Sun; Gui-rui Yan; Hai-peng Ding; Ying-xia Li; He-yao Wang; Wei-liang Zhu; Kai-xian Chen;
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作者单位

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年(卷),期 2013(34),11
年度 2013
页码 1397–1402
总页数 6
原文格式 PDF
正文语种
中图分类药学;
关键词
benzbromarone uricosuric drug fatty acid-binding protein 4 adipocyte diabetes db/db mouse molecular docking;

机译：苯溴马隆;尿酸排泄药物;脂肪酸结合蛋白4;脂肪细胞;糖尿病;db / db小鼠;分子对接;

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专利

1. Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice [J] . Hai-yan CAI, Ting WANG, Jian-chun ZHAO, 中国药理学报：英文版 . 2013,第011期

机译：苯溴马隆，一种旧的尿酸尿酸药物，可在体外抑制人脂肪酸结合蛋白4并降低db / db小鼠的血糖水平
2. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans [J] . Hiroshi Tsuneki, Mitsuyo Ishizuka, Miki Terasawa, BMC Pharmacology . 2004,第1期

机译：绿茶对糖尿病（db / db）小鼠血糖水平和血清蛋白质组学模式以及健康人葡萄糖代谢的影响
3. Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone [J] . Ahn Sung Oh, Ohtomo Shuichi, Kiyokawa Jumpei, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2016,第1期

机译：新型的选择性URAT1抑制剂UR-1102的更强尿酸尿酸作用使丛生的卷尾猴的血浆尿酸盐含量降低到比苯溴马隆更大的程度
4. The effect of different treatments for early lactation hyperketonemia on blood G-hydroxybutyrate, plasma non-esterified fatty acids, glucose, insulin, and glucagon in dairy cattle [C] . Annual Conference of the American Association of Bovine Practitioners . 2017

机译：早期哺乳期血液对血液G-羟基丁酯，血浆非酯化脂肪酸，葡萄糖，胰岛素和血糖素在乳制品中的影响
5. Molecular strategies for human nutrition: Screening for wild-caught salmon by fatty acid measurements and effects of foods on insulin levels in post-prandial fingerstick blood samples. [D] . Megdal, Peter A. 2009

机译：人类营养的分子策略：通过脂肪酸测量和食品对餐后指尖血液样本中胰岛素水平的影响，筛选野生鲑鱼。
6. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans [O] . Hiroshi Tsuneki, Mitsuyo Ishizuka, Miki Terasawa, 2004

机译：绿茶对糖尿病（db / db）小鼠血糖水平和血清蛋白质组学模式以及健康人葡萄糖代谢的影响
7. Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice [O] . Hai-yan Cai, Ting Wang, Jian-chun Zhao, 2013

机译：苯齐甘油酮，旧的尿囊药物，体外抑制人脂肪酸结合蛋白4，并降低DB / DB小鼠中的血糖水平

Benzbromarone an old uricosuric drug inhibits human fatty acid bindingprotein 4 in vitro and lowers the blood glucose level in db/dbmice

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