Tumor slices as a model to evaluate doxorubicin in vitro treatment and expression of trios of genes PRSS11 MTSS1 CLPTM1 and PRSS11 MTSS1 SMYD2 in canine mammary gland cancer

摘要

BackgroundIn women with breast cancer submitted to neoadjuvant chemotherapy based in doxorubicin, tumor expression of groups of three genes (PRSS11, MTSS1, CLPTM1 and PRSS11, MTSS1, SMYD2) have classified them as responsive or resistant. We have investigated whether expression of these trios of genes could predict mammary carcinoma response in dogs and whether tumor slices, which maintain epithelial-mesenchymal interactions, could be used to evaluate drug response in vitro.