Preparation Evaluation andOptimization of Multiparticulate System of Mebendazole for Colon Targeted DrugDelivery by Using Natural Polysaccharides

摘要

>Purpose: A Multiparticulate system of Mebendazole was developed for colon targeted drug delivery by using natural polysaccharides like Chitosan and Sodium-alginate beads. >Methods: Chitosan microspheres were formulated by using Emulsion crosslinking method using Glutaraldehyde as crosslinking agent. Sodium-alginate beads were formulated by using Calcium chloride as gelling agent. Optimization for Chitosan microspheres was carried out by using 2³ full factorial design. 3² full factorial design was used for the optimization of Sodium-alginate beads. The formulated batches were evaluated for percentage yield, particle size measurement, flow properties, percent entrapment efficiency, Swelling studies. The formulations were subjected to Stability studies and In-vitro release study (with and without rat caecal content). Release kinetics data was subjected to different dissolution models. >Results: The formulated batches showed acceptable particle size range as well as excellent flow properties. Entrapment efficiency for optimized batches of Chitosanmicrospheres and sodium alginate beads was found to be 74.18% and 88.48%respectively. In-vitro release of drug for the optimized batches was found tobe increased in presence of rat caecal content. The best-fit models were koresmeyer-peppasfor Chitosan microspheres and zero order for sodium-alginate beads.>Conclusion: Chitosan and Sodium-alginate was used successfully for the formulation of Colon targetedMultiparticulate system.