Molecular Targeting of Her-2eu Protein Is Not Recommended as an Adjuvant Therapy in Oral Squamous Cell Carcinoma and Oral Lichen Planus

摘要

>Purpose: Target therapy against molecular markers of EGFR family has been recently used in the treatment protocol of several diseases. However, the role of Her-2eu in OSCC is a matter of controversy and more studies are required to clarify the role of Her-2eu in OSCC. We aimed to investigate the role of Her-2eu in the process of carcinogenesis in oral epithelium as ELP is a premalignant and OSCC is a malignant lesion, but RLP shows no evidence of premalignancy and malignancy.To our Knowledge, this is the first study comparing Her-2eu expression in erosive lichen planus (ELP), reticular lichen planus (RLP), and oral squamous cell carcinoma (OSCC). >Methods: 60 samples, including 20 cases of RLP, 20 cases of ELP, and 20 cases of OSCC were evaluated immunohistochemically in this study. >Results: Our findings showed that there was not a significant increase in Her-2eu expression from RLP to ELP and from ELP to OSCC. Therefore, Her-2eu had no role in differentiating between RLP, ELP and OSCC and this protein does not contribute to the process of carcinogenesis in the oral epithelium. >Conclusion: The lack of Her-2eu overexpression indicates that molecular targeting of Her-2eu protein is not recommended as an adjuvant therapy in OSCC and OLP.