We aimed to assess whether and how changes in brain volume and increases in white matter hyperintensity (WMH) volume over three years predict gait speed and its change independently of demographics, vascular risk factors and physical status. We analyzed 443 individuals from the Lothian Birth Cohort 1936, at mean age 73 and 76 years. Gait speed at age 76 was predicted by age, grip strength and body mass index at mean age 73, three-year brain volume decrease and WMH volume increase, explaining 26.1% of variance. Decline in gait speed to age 76 was predicted by the same five variables explaining 40.9% of variance. In both analyses, grip strength and body mass index explained the most variance. A clinically significant decline in gait speed (≥ 0.1 m/s per year) occurred in 24.4%. These individuals had more structural brain changes. Brain volume and WMH changes were independent predictors of gait dysfunction and its three-year change, but the impact of malleable physical factors such as grip strength or body mass index was greater.
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机译：我们旨在评估三年内脑容量的变化以及白质高强度（WMH）数量的增加是否以及如何预测步态速度及其变化，而与人口统计学，血管危险因素和身体状况无关。我们分析了Lothian Birth Cohort 1936年的443个人，平均年龄为73岁和76岁。 76岁时的步态速度由年龄，平均年龄73岁时的握力和体重指数，三年大脑容量减少和WMH容量增加来预测，解释了26.1％的差异。相同的5个变量可预测到76岁的步态速度下降，从而解释了40.9％的差异。在两种分析中，握力和体重指数的差异最大。临床上步态速度的显着下降（每年≥0.1 m / s）占24.4％。这些人的大脑结构更具变化。脑容量和WMH变化是步态功能障碍及其三年变化的独立预测因子，但是可塑性身体因素（如握力或体重指数）的影响更大。
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