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The utility of self-emulsifying oil formulation to improve the poor solubility of the anti HIV drug CSIC

机译：自乳化油配方可改善抗HIV药物CSIC的不良溶解性

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摘要

BackgroundCSIC (5-chloro-3-phenylsulfonylindole-2-carboxamide), a non-nucleoside reverse transcriptase inhibitor (NNRTI) has not been advanced as a therapeutic anti-HIV candidate drug due to its low aqueous solubility and poor bioavailability.

机译：背景技术CSIC（5-氯-3-苯基磺酰吲哚-2-羧酰胺），一种非核苷类逆转录酶抑制剂（NNRTI），由于其水溶性低和生物利用度差而尚未发展为抗HIV候选药物。

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期刊名称 AIDS Research and Therapy
作者
Nicholas C Obitte; Lisa C Rohan; Christianah M Adeyeye; Michael A Parniak; Charles O Esimone;
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作者单位

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年(卷),期 2013(10),-1
年度 2013
页码 14
总页数 9
原文格式 PDF
正文语种
中图分类病毒传染病;
关键词
Anti-HIV Poorly soluble Self-emulsification CSIC Bioactivity Anhydrous emulsion;

机译：抗艾滋病毒;难溶;自乳化;CSIC;生物活性;无水乳液;

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专利

1. The utility of self-emulsifying oil formulation to improve the poor solubility of the anti HIV drug CSIC [J] . Nicholas C Obitte, Lisa C Rohan, Christianah M Adeyeye, AIDS Research and Therapy . 2013,第1期

机译：自乳化油配方可改善抗HIV药物CSIC的不良溶解性
2. Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs. [J] . Gao P, Morozowich W Expert opinion on drug delivery . 2006,第1期

机译：开发用于改善难溶性药物的口服吸收的超饱和自乳化药物输送系统制剂。
3. Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs [J] . Puneet Sharma, Sanjay Garg Advanced drug delivery reviews . 2010,第4a5期

机译：基于纯药物和聚合物的纳米技术，可提高抗HIV药物的溶解度，稳定性，生物利用度和靶向性
4. Non-Spherical Droplets: Instabilities of a Self-Emulsifying Formulation (SEF) Containing aPoorly Water-Soluble Drug [C] . A. Mercuri, D. Q. M. Craig, S. A. Barker Annual meeting exposition of the Controlled Release Society . 2009

机译：非球形液滴：含有水溶性差的药物的自乳化制剂（SEF）的不稳定性
5. Formulation and in-vitro and in-vivo testing of a phenytoin self-emulsifying drug delivery system (SEDDS). [D] . Atef, Eman. 2004

机译：苯妥英自乳化药物递送系统（SEDDS）的配制以及体外和体内测试。
6. Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention [O] . Tiantian Gong, Wei Zhang, Michael A. Parniak, -1

机译：预防艾滋病的杀菌剂候选CSIC的预配制和阴道膜制剂开发
7. The utility of self-emulsifying oil formulation to improve the poor solubility of the anti HIV drug CSIC [O] . Nicholas C Obitte, Lisa C Rohan, Christianah M Adeyeye, 2013

机译：自乳化油配方可改善抗HIV药物CSIC的不良溶解性

The utility of self-emulsifying oil formulation to improve the poor solubility of the anti HIV drug CSIC

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