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The effect of cyclodextrin-solubilized curcuminoids on amyloid plaques in Alzheimer transgenic mice: brain uptake and metabolism after intravenous and subcutaneous injection

机译：环糊精增溶的姜黄素对阿尔茨海默病转基因小鼠淀粉样斑块的影响：静脉内和皮下注射后脑摄取和代谢

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IntroductionCurcuminoids may improve pathological conditions associated with Alzheimer's disease. However, their therapeutic potential is limited by their exceedingly low bioavailability after oral administration. A method to deliver solubilized curcuminoids by injection was evaluated in Alzheimer transgenic mice.

机译：简介姜黄素可以改善与阿尔茨海默氏病相关的病理状况。但是，它们的治疗潜力受到口服给药后极低的生物利用度的限制。在阿尔茨海默氏病转基因小鼠中评估了通过注射递送溶解的姜黄素的方法。

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期刊名称 Alzheimers Research Therapy
作者
Wolfgang W Quitschke; Nicole Steinhauff; Jean Rooney;
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年(卷),期 2013(5),2
年度 2013
页码 16
总页数 15
原文格式 PDF
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中图分类精神病学 ;
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专利

1. The effect of cyclodextrin-solubilized curcuminoids on amyloid plaques in Alzheimer transgenic mice: brain uptake and metabolism after intravenous and subcutaneous injection [J] . Wolfgang W Quitschke, Nicole Steinhauff, Jean Rooney Alzheimer s Research & Therapy . 2013 ,第2期

机译：环糊精增溶的姜黄素对阿尔茨海默病转基因小鼠淀粉样斑块的影响：静脉内和皮下注射后脑摄取和代谢
2. The effect of cyclodextrin-solubilized curcuminoids on amyloid plaques in Alzheimer transgenic mice: brain uptake and metabolism after intravenous and subcutaneous injection [J] . Wolfgang W Quitschke, Nicole Steinhauff, Jean Rooney Alzheimer's Research & Therapy . 2013 ,第2期

机译：环糊精增溶的姜黄素对阿尔茨海默病转基因小鼠淀粉样斑块的影响：静脉内和皮下注射后脑摄取和代谢
3. Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the abeta amyloid peptide [J] . SumbriaR.K., HuiE.K.-W., LuJ.Z., Molecular pharmaceutics . 2013 ,第9期

机译：每天皮下注射靶向转铁蛋白受体和abeta淀粉样蛋白肽的四价双特异性抗体，可在阿尔茨海默氏病转基因小鼠的大脑中分解淀粉样蛋白斑块
4. Fully Automated and Adaptive Detection of Amyloid Plaques in Stained Brain Sections of Alzheimer Transgenic Mice [C] . Abdelmonem Feki, Olivier Teboul, Albertine Dubois, International Conference on Medical Image Computing and Computer-Assisted Intervention(MICCAI 2007) pt.2; 20071029-1102; Brisbane(AU) . 2007

机译：阿尔茨海默氏病转基因小鼠染色的脑部淀粉样斑块的全自动和自适应检测。
5. Genetic ablation of the platelet activating factor receptor does not impair learning and memory in wild-type mice or alter amyloid plaque number in a transgenic model of Alzheimer's disease [D] . Peshdary, Vian. 2012

机译：血小板活化因子受体的遗传消融不会损害野生型小鼠的学习和记忆，也不会改变阿尔茨海默氏病转基因模型中的淀粉样斑块数
6. Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation Amyloid Beta and Tau Pathologies in 5XFAD Transgenic Mice [O] . Sarah Houben, Marie-Ange de Fisenne, Kunie Ando, 2020

机译：静脉注射来自阿尔茨海默脑的PHF-TAU蛋白加剧了5xFAD转基因小鼠的神经炎症淀粉样蛋白β和TAU病理
7. The effect of cyclodextrin-solubilized curcuminoids on amyloid plaques in Alzheimer transgenic mice: brain uptake and metabolism after intravenous and subcutaneous injection [O] . Wolfgang W Quitschke, Nicole Steinhauff, Jean Rooney 2013

机译：环糊精增溶的姜黄素对阿尔茨海默病转基因小鼠淀粉样斑块的影响：静脉内和皮下注射后脑摄取和代谢

The effect of cyclodextrin-solubilized curcuminoids on amyloid plaques in Alzheimer transgenic mice: brain uptake and metabolism after intravenous and subcutaneous injection

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