Seizure risk has consistently been found to be higher in offspring of mothers than of fathers with epilepsy. This pattern cannot be explained by any simple genetic model. The present study examined the possibility that the pattern arises from differences between affected mothers and fathers in the characteristics of their epilepsy that influence offspring seizure risk. The study population comprised 687 offspring of parents with epilepsy from the Rochester-Olmsted County Record Linkage Project. Cumulative incidences of unprovoked seizures to age 25 were 8.7% and 2.4% in offspring of affected mothers and fathers, respectively. Cox proportional hazards analysis was used to calculate rate ratios (RRs) for unprovoked seizures in offspring. In the univariate analysis, risk of unprovoked seizures was higher if the affected parent was the mother (RR = 2.8, 95% confidence interval [ci] 1.1-7.2) or if the parent's onset was before age 20 (RR = 2.5, 95% ci 1.1-5.9), but there was no effect on offspring risk of either parent's etiology (idiopathic vs. remote symptomatic) or parent's seizure type (generalized vs. partial). These findings were not substantially changed in the multivariate analysis. Thus, differences between affected mothers and fathers in these characteristics did not account for the higher risk in offspring of affected mothers. Anticonvulsant use during pregnancy was not associated with increased offspring seizure risk.(ABSTRACT TRUNCATED AT 250 WORDS)
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机译:一直以来发现,患有癫痫病的母亲的后代患癫痫风险要高于父亲。任何简单的遗传模型都无法解释这种模式。本研究检验了这种模式是否可能是由于受影响的父母之间在影响子代癫痫发作风险的癫痫特征方面存在差异而引起的。研究人群包括来自罗切斯特-奥尔姆斯特德县记录连锁项目的687名患有癫痫病的父母的后代。在受影响的母亲和父亲的后代中,到25岁时无缘无故发作的累积发生率分别为8.7%和2.4%。使用Cox比例风险分析来计算后代无故癫痫发作的比率(RRs)。在单因素分析中,如果受影响的父母是母亲(RR = 2.8,95%置信区间[ci] 1.1-7.2)或父母的发病年龄在20岁之前(RR = 2.5,95%),则无故发作的风险较高。 ci 1.1-5.9),但对父母病因(特发性与偏远症状)或父母癫痫发作类型(普遍性与部分性)的后代风险没有影响。这些发现在多变量分析中没有实质性改变。因此,受影响的父母之间在这些特征上的差异并不能说明受影响的母亲的后代具有更高的风险。怀孕期间使用抗惊厥药与后代癫痫发作风险增加无关(摘要截断为250字)
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