Therapy of 125I particles implantation inhibited the local growth of advanced non-small cell lung cancer: a retrospective clinical study

摘要

Background: The aim of this study was to investigate the efficacy and safety of ¹²⁵I particle implantation for treating advanced non-small cell lung cancer (NSCLC). Methods: Data from 56 patients with advanced NSCLC between January 2013 and May 2016 were retrospectively analyzed. The changes of tumor size, objective response rate (ORR), disease control rate (DCR), survival rate of patients and occurrence rate of complications were calculated, and the levels of carcinoembryonic antigen (CEA) and cytokerantin-19-fragment (CYFRA21-1) before and after the treatment were evaluated. Results: The ¹²⁵I particles implantation therapy significantly inhibited the tumor local growth of NSCLC (from 7.75±6.69 to 3.39±2.12 cm) (P<0.001), suggesting a better effectiveness with an RR of 55.4% and DCR of 98.2%. In addition, the ¹²⁵I particle implantation down-regulated the CEA expression level of lung adenocarcinoma (LAC) patients (P<0.05). The one-year, two-year, three-year survival rate were 41.1%, 39.3% and 19.6% respectively after the implantation therapy. However, patients implanted ¹²⁵I particles had no serious complications except for slight fever. Conclusions: NSCLC patients at different clinical features all can benefit from the ¹²⁵I particle implantation therapy. Moreover, the level of CEA can be used as an efficacy predictor for the ¹²⁵I particle implantation therapy for LAC.