AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS

摘要

In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2-substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3-(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhibitory concentration (MIC) values are determined, The MIC of pyrazoles and pyrido[1,2 -a] pyrimidines are found to be 25 μg/ml to 50 μg/ml against E. Coli and 50 μg/ml against B.subtilis respectively. Both pyrazole and pyrido [1,2-a] Pyrimidines are found to be totally ineffective against C. albicans.