Synergistic effect of metformin on sorafenib in in vitro study using hepatocellular carcinoma cell lines

摘要

Backgrounds/AimsHepatocellular carcinoma (HCC) recurrence remains a great concern following hepatic resection and liver transplantation. We investigated the metformin-induced cytotoxic effects on sorafenib in an in vitro study using HCC cell lines.