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Long term NSAID treatment inhibits COX‐2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac

机译：长期NSAID治疗会抑制骨关节炎患者膝滑膜中COX-2的合成：塞来昔布和醋氯芬酸之间促炎性细胞因子的差异

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摘要

ObjectiveTo compare the effect of celecoxib with that of a classic non‐steroidal anti‐inflammatory drug (NSAID) on synovial inflammation and on the synovial expression of proinflammatory genes in patients with knee osteoarthritis (OA).

机译：目的比较塞来昔布和经典非甾体类抗炎药（NSAID）对膝骨关节炎（OA）患者滑膜炎症和促炎基因滑膜表达的影响。

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期刊名称 Annals of the Rheumatic Diseases
作者
M A Álvarez‐Soria; R Largo; J Santillana; O Sánchez‐Pernaute; E Calvo; M Hernández; J Egido; G Herrero‐Beaumont;
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作者单位

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年(卷),期 2006(65),8
年度 2006
页码 998–1005
总页数 8
原文格式 PDF
正文语种
中图分类免疫性疾病 ;
关键词
osteoarthritis COX‐2 synovial membrane non‐steroidal anti‐inflammatory drugs celecoxib;

机译：骨关节炎;COX-2;滑膜;非甾体抗炎药;塞来昔布;

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专利

1. The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders. [J] . Wassilew GI, Lehnigk U, Duda GN, Arthroscopy: the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association . 2011 ,第8期

机译：与膝关节外伤相比，骨关节炎患者滑膜中促炎细胞因子和基质金属蛋白酶的表达。
2. Percutaneously absorbed NSAIDs attenuate local production of proinflammatory cytokines and suppress the expression of c-Fos in the spinal cord of a rodent model of knee osteoarthritis. [J] . Orita S, Ishikawa T, Miyagi M, Journal of orthopaedic science : . 2012 ,第1期

机译：经皮吸收的NSAIDs减轻了膝骨关节炎啮齿动物模型脊髓中促炎性细胞因子的局部产生并抑制了c-Fos的表达。
3. Percutaneously absorbed NSAIDs attenuate local production of proinflammatory cytokines and suppress the expression of c-Fos in the spinal cord of a rodent model of knee osteoarthritis [J] . Sumihisa Orita, Tetsuhiro Ishikawa, Masayuki Miyagi, Journal of Orthopaedic Science . 2012 ,第1期

机译：经皮吸收的NSAIDs减轻了膝骨关节炎啮齿动物模型脊髓中促炎性细胞因子的局部产生并抑制了c-Fos的表达
4. TREATMENT SOLUTIONS OF SYNOVIAL JOINTS AND RECOVERY PROCESSES OF PATIENTS WITH HIP AND KNEE OSTEOARTHRITIS [C] . Petru A. Pop, Petru Ungur, Liviu Lazar International Mechanical Engineering Congress and Exposition . 2010

机译：髋关节和膝关节骨关节炎患者滑膜关节和恢复过程的处理解决方案
5. Long Term Assessment of Patient Treatment Preferences for Knee Osteoarthritis [D] . de Achaval, Sofia. 2018

机译：对膝骨关节炎患者的治疗偏爱的长期评估
6. Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee [O] . Sumihisa Orita, Takana Koshi, Takeshi Mitsuka, 2011

机译：连续47例膝关节骨关节炎患者滑液中促炎细胞因子与放射学分级和疼痛相关评分之间的关系
7. Long term NSAID treatment inhibits COX‐2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac [O] . Álvarez‐Soria, M A, Largo, R, Santillana, J, 2006

机译：长期NSAID治疗会抑制骨关节炎患者膝滑膜中COX-2的合成：塞来昔布和醋氯芬酸之间促炎性细胞因子的差异

Long term NSAID treatment inhibits COX‐2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac

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