Heat Shock Preconditioning Reduces Ischemic Tissue Necrosis by Heat Shock Protein (HSP)-32-Mediated Improvement of the Microcirculation Rather Than Induction of Ischemic Tolerance

摘要

Introduction:Supraphysiologic stress induces a heat shock response, which may exert protection against ischemic necrosis. Herein we analyzed in vivo whether the induction of heat shock protein (HSP) 32 improves survival of chronically ischemic myocutaneous tissue, and whether this is based on amelioration of microvascular perfusion or induction of ischemic tolerance.