AB033. The role in cancer-related DNA damage repair of RNF43

摘要

BackgroundCancer is a chronic disease and currently the leading cause of death in Thailand. Functional defect of DNA repair pathway in cells plays role carcinogenesis. Conversely, cancer cells also remain the trace DNA repair pathway to survive under the genotoxic environment, i.e., chemotherapy, and result in resistance to the treatment. Previous reports have shown that DNA repair targeted therapy could improve the conventional treatment. The Ring Finger E3 ubiquitin ligase gene (RNF43) is of interest because the function in tumorigenesis related to DNA repair mechanism is ambiguous. Ubiquitin post-translational modification involves in many cellular processes, such as proteasomal degradation and DNA repair regulation. A number of studies indicated contribution of RNF43 toward proteasomal degradation of Frizzled receptor that is related to carcinogenesis. However, there has been no study investigating molecular mechanism of RNF43 on the DNA repair process which could participate in cancer.