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In Vitro Activity of Retapamulin against Staphylococcus aureus Resistant to Various Antimicrobial Agents

机译：维他命A对各种抗微生物药物耐药的金黄色葡萄球菌的体外活性

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Retapamulin and six other antimicrobial agents were evaluated against 155 methicillin-resistant Staphylococcus aureus (MRSA) isolates, including strains resistant to vancomycin, linezolid, daptomycin, and mupirocin by microdilution tests. Time-kill assays were performed against representative MRSA, vancomycin-intermediate S. aureus (VISA), and vancomycin-resistant S. aureus (VRSA) isolates. Retapamulin and mupirocin demonstrated MIC90s of 0.12 μg/ml and 8 μg/ml, respectively, with resistance seen in 2.6% and 10% of isolates, respectively. Retapamulin maintained good activity against 94% (15/16) of mupirocin-resistant isolates.

机译：通过微稀释试验评估了瑞塔帕米林和其他六种抗菌剂对155种耐甲氧西林金黄色葡萄球菌（MRSA）菌株的抵抗力，包括对万古霉素，利奈唑胺，达托霉素和莫匹罗星具有抗性的菌株。针对代表性的MRSA，万古霉素中间体金黄色葡萄球菌（VISA）和耐万古霉素的金黄色葡萄球菌（VRSA）分离株进行了时间杀灭试验。维他命A和莫匹罗星的MIC90分别为0.12μg/ ml和8μg/ ml，在分离株中分别有2.6％和10％的耐药性。维他命A对94％（15/16）耐莫匹罗星的分离株保持良好的活性。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
Louis D. Saravolatz; Joan Pawlak; Stephanie N. Saravolatz; Leonard B. Johnson;
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年(卷),期 2013(57),9
年度 2013
页码 4547–4550
总页数 4
原文格式 PDF
正文语种
中图分类药学 ; 微生物学 ;
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1. In vitro activity of Retapamulin against Staphylococcus aureus resistant to various antimicrobial agents [J] . SaravolatzL.D., PawlakJ., SaravolatzS.N., Antimicrobial agents and chemotherapy. . 2013 ,第9期

机译：维他命A对各种耐药菌耐药的金黄色葡萄球菌的体外活性
2. In Vitro Activity of Retapamulin and Antimicrobial Susceptibility Patterns in a Longitudinal Collection of Methicillin-Resistant Staphylococcus aureus Isolates from a Veterans Affairs Medical Center [J] . Harrington Amanda T., Black Jennifer A., Clarridge Jill E. III Antimicrobial agents and chemotherapy. . 2016 ,第3期

机译：退伍军人抗药性金黄色葡萄球菌分离株的纵向收集物中瑞达木霉素的体外活性和抗菌药敏感性模式
3. In Vitro Antimicrobial Activities of Fusidic Acid and Retapamulin against Mupirocin- and Methicillin-Resistant Staphylococcus aureus [J] . Park Sang Hyun, Kim Jin Kyung, Park Kun Annals of Dermatology . 2015 ,第5期

机译：夫西地酸和瑞他帕米林对耐莫匹罗星和耐甲氧西林的金黄色葡萄球菌的体外抗菌活性
4. Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa. [C] . David Medina, Thomas J. Webster Society for Biomaterials annual meeting and exposition . 2018

机译：金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌（MRSA），大肠杆菌和铜绿假单胞菌制成的具有抗菌特性的生物硒纳米粒子的合成与表征。
5. Influence of in vitro bacterial urokinase responsiveness on the in vivo pathogenesis of methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in mouse models. [D] . Yanke, Shawna Janine. 2000

机译：体外细菌尿激酶反应性对小鼠模型中甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林的金黄色葡萄球菌的体内发病机理的影响。
6. In Vitro Activity of Retapamulin and Antimicrobial Susceptibility Patterns in a Longitudinal Collection of Methicillin-Resistant Staphylococcus aureus Isolates from a Veterans Affairs Medical Center [O] . Amanda T. Harrington, Jennifer A. Black, Jill E. Clarridge III 2016

机译：退伍军人抗药性金黄色葡萄球菌分离株纵向收集物中瑞达木霉素的体外活性和抗菌药敏感性模式
7. In vitro Activity of Some Antimicrobial Agents against Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus in Khartoum, Sudan [O] . H.A. Saeed, W.B. Ahmed 2009

机译：在苏丹喀土穆的葡萄球菌含有金黄色葡萄球菌和耐甲氧西林含金葡萄球菌的体外活性

In Vitro Activity of Retapamulin against Staphylococcus aureus Resistant to Various Antimicrobial Agents

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