Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis

机译：雾化两性霉素B联合静脉两性霉素B在严重侵袭性肺曲霉病大鼠中的作用

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摘要

Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.

机译：在持续性白细胞减少症的侵袭性肺曲霉病大鼠中，研究了雾化的两性霉素B（AMB）与静脉内AMB的组合。气雾剂处理后AMB的肺浓度显着高于静脉内脂质体AMB后。与对照组相比，雾化脂质体AMB以及静脉AMB均可显着延长生存期。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
Elisabeth J. Ruijgrok; Marcel H. A. M. Fens; Irma A. J. M. Bakker-Woudenberg; Els W. M. van Etten; Arnold G. Vulto;
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作者单位

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年(卷),期 2006(50),5
年度 2006
页码 1852–1854
总页数 3
原文格式 PDF
正文语种
中图分类药学;微生物学;
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专利

1. Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis. [J] . Ruijgrok EJ, Fens MH, Bakker Woudenberg IA, Antimicrobial agents and chemotherapy. . 2006,第5期

机译：雾化的两性霉素B与静脉内的两性霉素B联合治疗患有严重浸润性肺曲霉病的大鼠。
2. Efficacy of aerosolized amphotericin B desoxycholate and liposomal amphotericin B in the treatment of invasive pulmonary aspergillosis in severely immunocompromised rats. [J] . Ruijgrok EJ, pdz.azr.nl, Vulto AG, The Journal of Antimicrobial Chemotherapy . 2001,第1期

机译：雾化的两性霉素B脱氧胆酸盐和脂质体两性霉素B在严重免疫受损的大鼠中治疗侵袭性肺曲霉病的功效。
3. Nebulized liposomal amphotericin B and combined systemic antifungal therapy for the treatment of severe pulmonary aspergillosis after allogeneic hematopoietic stem cell transplant for a fatal mitochondrial disorder. [J] . Castagnola E, Moresco L, Cappelli B, Journal of chemotherapy . 2007,第3期

机译：雾化的两性霉素B脂质体和系统性抗真菌治疗相结合，用于治疗致命性线粒体疾病的异基因造血干细胞移植后的严重肺曲霉病。
4. AMPHOTERICIN B COCHLEATES : EVALUATION FOR THE ORAL TREATMENT OF ASPERGILLOSIS IN A MURINE MODEL [C] . G. Delmas, D. Perlin, Z.W. Chen, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：两性霉素乙酸盐的口服评价：小鼠模型中口服孢菌的评价。
5. The role of CC chemokine receptor 7 during pulmonary invasive aspergillosis. [D] . Hartigan, Adam Joseph. 2009

机译：CC趋化因子受体7在肺部侵袭性曲霉病中的作用。
6. Pharmacokinetics and Pharmacodynamics of Amphotericin B Deoxycholate Liposomal Amphotericin B and Amphotericin B Lipid Complex in an In Vitro Model of Invasive Pulmonary Aspergillosis [O] . Jodi M. Lestner, Susan J. Howard, Joanne Goodwin, 2010

机译：两性霉素B脱氧胆酸盐脂质体两性霉素B和两性霉素B脂质复合物在体外侵袭性肺曲霉病模型中的药代动力学和药效学
7. Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis [O] . Ruijgrok, Elisabeth J., Fens, Marcel H. A. M., Bakker-Woudenberg, Irma A. J. M., 2006

机译：雾化两性霉素B联合静脉两性霉素B在严重侵袭性肺曲霉病大鼠中的作用
8. Lethal Pulmonary Reactions Associated with the Combined Use of Amphotericin B and Leukocyte Transfusions [R] . Wright, D. G., Robichaud, K. J., Pizzo, P. A., 1979

机译：与两性霉素B和白细胞输注联合使用相关的致死性肺反应

Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis

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