Activity of Retapamulin (SB-275833) a Novel Pleuromutilin against Selected Resistant Gram-Positive Cocci

机译：Retapamulin（SB-275833）一种新型截短侧耳素对所选抗革兰氏阳性球菌的活性

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Retapamulin (SB-275833), the first pleuromutilin to be developed for human topical use, was tested against a selected population of staphylococci and β-hemolytic streptococci. The MIC90 results for retapamulin were 0.12 μg/ml for Staphylococcus aureus and ≤0.03 μg/ml for Streptococcus pyogenes; no cross-resistance was observed for organism subsets resistant to oxacillin, erythromycin, or mupirocin.

机译：维他命mulin（SB-275833）是开发用于人类局部使用的第一种截短侧耳素，已针对选定的葡萄球菌和β-溶血性链球菌进行了测试。 retapamulin的MIC90结果为金黄色葡萄球菌为0.12μg/ ml，化脓链球菌为≤0.03μg/ ml。对奥沙西林，红霉素或莫匹罗星具有抗性的生物亚群未观察到交叉耐药性。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
Ronald N. Jones; Thomas R. Fritsche; Helio S. Sader; James E. Ross;
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年(卷),期 2006(50),7
年度 2006
页码 2583–2586
总页数 4
原文格式 PDF
正文语种
中图分类药学;微生物学;
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专利

1. Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. [J] . Jones RN, Fritsche TR, Sader HS, Antimicrobial agents and chemotherapy. . 2006,第7期

机译：新型截短侧耳素retapamulin（SB-275833）对选定的耐药革兰氏阳性球菌的活性。
2. Comparative study of new benzenesulphonamide fluoroquinolones structurally related to ciprofloxacin against selected ciprofloxacin-susceptible and -resistant Gram-positive cocci. [J] . Alovero F, Barnes A, Nieto M, The Journal of Antimicrobial Chemotherapy . 2001,第5期

机译：在结构上与环丙沙星有关的新型苯磺酰胺氟喹诺酮类药物对选定的环丙沙星敏感和耐药革兰氏阳性球菌的比较研究。
3. Pleuromutilin derivatives having a purine ring. Part 1: new compounds with promising antibacterial activity against resistant Gram-positive pathogens. [J] . Hirokawa Y, Kinoshita H, Tanaka T, Bioorganic and Medicinal Chemistry Letters . 2008,第12期

机译：具有嘌呤环的截短侧耳素衍生物。第1部分：对抗革兰氏阳性病原体具有有希望的抗菌活性的新化合物。
4. Design of New Antimicrobial Peptides (AMPs) with "Specificity Determinants" that Encode Selectivity for Gram-negative Pathogens and Remove both Gram-positive Activity and Hemolytic Activity from Broad-spectrum AMPs [C] . Ziqing Jiang, Lajos Gera, Colin T. Mant American Peptide Symposium . 2015

机译：具有“特异性决定因素”的新抗菌肽（AMPS）的设计，即编码革兰阴性病原体的选择性，并从广谱安培中去除革兰氏阳性活性和溶血活性
5. Development of Methods for Anti-Markovnikov Functionalization of Terminal Alkynes And Enantioselective and Modular Synthesis of Pleuromutilins [D] . Zeng, Mingshuo. 2017

机译：末端炔烃抗Markovnikov功能化和截短侧耳素的对映选择性和模块合成方法的开发
6. In vitro activities of ramoplanin selected glycopeptides fluoroquinolones and other antibiotics against clinical bloodstream isolates of gram-positive cocci. [O] . T Lawrence, C Rotstein, T R Beam Jr, 1993

机译：雷莫拉宁所选糖肽氟喹诺酮和其他抗生素对革兰氏阳性球菌临床血流分离物的体外活性。
7. Activity of Retapamulin (SB-275833), a Novel Pleuromutilin, against Selected Resistant Gram-Positive Cocci [O] . Jones, Ronald N., Fritsche, Thomas R., Sader, Helio S., 2006

机译：Retapamulin（SB-275833），一种新型截短侧耳素，对所选抗革兰氏阳性球菌的活性
8. Enhancement of Growth of Aerobic, Anaerobic, and Facultative Bacteria in Mixed Infections with Anaerobic and Facultative Gram-Positive Cocci [R] . Brook, I. 1988

机译：厌氧和兼性革兰氏阳性球菌混合感染中好氧，厌氧和兼性细菌生长的增强

Activity of Retapamulin (SB-275833) a Novel Pleuromutilin against Selected Resistant Gram-Positive Cocci

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