>Aims: To determine the haematological effects of iron supplementation in predominantly breast fed term low birth weight (LBW) infants. >Methods: Seventy three healthy term LBW (<2500 g), predominantly breast fed infants aged 50–80 days were randomised into two groups to receive either iron (3 mg/kg/day) (iron supplemented (IS) group; n = 37) or placebo drops (placebo (P) group; n = 36). Haematological parameters and anthropometry were measured at baseline and repeated after four and eight weeks. >Results: A total of 62 subjects (32 in the IS group and 30 in the P group) came for the first follow up and 26 (13 in the IS group and 13 in the P group) reported for the second visit. There were no significant differences in serum ferritin and anthropometry. However, covariates (infant age, haemoglobin, and ferritin, and maternal haemoglobin) adjusted haemoglobin change was significantly higher in the IS group after four weeks (4.6 g/l; 95% CI 0.5 to 8.8) and eight weeks (8.6 g/l; 95% CI 1.8 to 15.4). >Conclusions: Iron supplementation in a therapeutic dose in term breast fed LBW infants results in a marginal increase in haemoglobin. The functional benefit of this haemoglobin rise requires further evaluation.
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机译：>目的：确定主要在母乳喂养的足月低体重（LBW）婴儿中补充铁的血液学影响。 >方法：将七十名健康足月体重不足（<2500 g），主要是50-80天的母乳喂养婴儿随机分为两组，分别接受铁（3 mg / kg /天）（补充铁（ IS）组； n = 37）或安慰剂滴剂（安慰剂（P）组； n = 36）。在基线时测量血液学参数和人体测量学，并在四，八周后重复进行。 >结果：共有62位受试者（IS组32位，P组30位）进行了首次随访，报道了26位受试者（IS组13位，P组13位）。第二次访问。血清铁蛋白和人体测量法无显着差异。但是，IS组在四周（4.6 g / l； 95％CI 0.5至8.8）和八周（8.6 g / l）后，协变量（婴儿年龄，血红蛋白，铁蛋白和母体血红蛋白）调整的血红蛋白变化明显更高。 ； 95％CI为1.8至15.4）。 >结论：足月母乳喂养的LBW婴儿按治疗剂量补充铁后，血红蛋白略有增加。这种血红蛋白升高的功能益处需要进一步评估。
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