Concentrations of various plasma lipid fractions were determined during 96 hours of continuous parenteral infusions of lipid emulsions in 10 normally-grown neonates whose birth-weights ranged from 960 to 1760 g and whose gestational ages ranged from 26 to 32 weeks. Total lipid, triglyceride, free glycerol, and free fatty acid concentrations were measured. During lipid infusions, mean plasma concentrations of all lipid fractions increased above the mean preinfusion values if 2 g/kg a day or more of lipid emulsion was used. There were no further significant increases in mean plasma lipid levels if the infused dosage was increased to 3 or 4 g/kg a day. At these higher infusion rates however, there were considerable individual variations. The only neonate less than 27 weeks of gestation had plasma lipid levels severalfold higher than any of his peers, his plasma was frankly creamy on visual inspection, and the study had to be stopped. Further investigations are needed to determine the optimal modalities of parenteral nutrition with fat emulsions.
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机译：在10例正常生长的新生儿中，在连续肠胃外注射脂质乳剂的96小时内，测定了各种血浆脂质成分的浓度，这些新生儿的出生体重在960至1760 g之间，胎龄在26至32周之间。测量总脂质，甘油三酸酯，游离甘油和游离脂肪酸的浓度。在脂质输注过程中，如果每天使用2 g / kg或更多的脂质乳剂，则所有脂质部分的平均血浆浓度会增加到高于平均输注前值。如果输注剂量增加到每天3或4 g / kg，平均血浆脂质水平不会进一步显着增加。然而，在这些较高的输注速度下，会有很大的个体差异。唯一怀孕少于27周的新生儿的血脂水平比其他同龄人高出几倍，在目视检查中坦率地说，他的血浆呈乳脂状，因此必须停止研究。需要进一步的研究以确定脂肪乳剂肠胃外营养的最佳方式。
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