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Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases.

机译:多发性先天性关节炎。搜寻66例散发病例中的产前因素。

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摘要

In a family and epidemiological survey of 66 cases of arthrogryposis multiplex congenita all cases were found to be sporadic and no family association with clubfoot, congenital dislocation of the hip, or hereditary neuromuscular disease was found. The mothers were significantly older than average. Oligohydramnios was noted in only one-third of cases but many other complications of pregnancy, including probable attempts at abortion, had occurred. It is likely that most cases of arthrogryposis are nongenetic and result from a defective intrauterine environment, whether hormonal, vascular, mechanical, or possibly infective.
机译:在一项针对66例多发性先天性关节炎的家庭和流行病学调查中,所有病例都是零星的,没有发现与马蹄内翻足,先天性髋关节脱位或遗传性神经肌肉疾病相关的家庭。母亲比平均年龄大得多。羊水过少仅发生在三分之一的病例中,但发生了许多其他妊娠并发症,包括可能的流产尝试。大多数关节软化病例可能是非遗传性的,是由于子宫内环境不良所致,无论是激素,血管,机械的还是可能的感染。

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