Evaluation of Collagen Fibers MMP2 MMP9 8-OHdG and Apoptosis inthe Aorta of Ovariectomized LDL Knockout Mice Submitted to AerobicExercise

摘要

BackgroundIn menopause, there is greater cellular exposure to oxidative stress, related to the decreased antioxidative effects of estrogen. These metabolic changes favor the progression of cardiovascular diseases, such as atherosclerosis. Abnormal function of the aorta - the most important artery - is associated with many cardiovascular diseases. Collagen, especially types I and III, is one of the most important aortic wall components and it can be affected by many factors, including menopause. The 8-OHdG is one of the main markers of DNA oxidative damage induced by reactive oxygen species (ROS).